Brugada-like Electrocardiographic Pattern Unmasked by Fever

Wakita, Rie; Watanabe, Ichiro; Okumura, Yasuo; Yamada, Takeshi; Takagi, Yasuhiro; Kofune, Tatsuya; Okubo, Kimie; Masaki, Riko; Sugimura, Hidezou; Oshikawa, Naohiro; Saito, Satoshi; Ozawa, Yukio; Kanmatsuse, Katsuo

doi:10.1536/jhj.45.163

Cited by 20 publications

(3 citation statements)

References 13 publications

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“…We did a comprehensive literature search using different Medical Subject Heading (MeSH) terms and reviewed all the available literature on unmasking or new onset of Brugada pattern and Brugada syndrome. Our search revealed a total of 65 cases as mentioned in online supplementary table 1 6–70. The mean age of the reported patients was 42 years (1.5–80) with 85% (n=60) males and 15% (n=11) females.…”

Section: Discussionmentioning

confidence: 99%

Brugada pattern: a comprehensive review on the demographic and clinical spectrum

Abbas

Roomi

Ullah³

et al. 2019

BMJ Case Rep

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A prominent coved or saddle-shaped ST-segment elevation followed by T wave changes in V1-V3 and in the absence of other identifiable cause is termed as Brugada pattern. This pattern in the presence of documented ventricular arrhythmias or its symptoms (syncope, seizure) or significant family for sudden cardiac death or abovementioned ECG changes is called Brugada syndrome. Here we present a comprehensive literature review on the precipitation factors of Brugada syndrome/pattern by various stimuli, its presentation, associations, management and outcomes. We are also presenting a unique case of Brugada pattern where the patient’s Brugada pattern was unmasked at an extreme old age by infection.

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Section: Discussionmentioning

confidence: 99%

Brugada pattern: a comprehensive review on the demographic and clinical spectrum

Abbas

Roomi

Ullah³

et al. 2019

BMJ Case Rep

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“…We were unable to perform EPS to our patient. Febrile state, in conjunction with other factors has been shown to unmask the Brugada pattern on the ECG and trigger arrhythmias which may have initially be concealed (Wakita et al, 2004;Adler et al, 2013). Fever, in our patient may have led to the exposure of his Brugada-pattern ECG as the consequent ECG post febrile condition was normal.…”

Section: Discussionmentioning

confidence: 51%

Brugada-like syndrome presenting with monomorphic ventricular tachycardia and Brugada-type electrocardiogram unmasked by fever in an infant: a case report

Kilonzo

Ringo

Steven

et al. 2015

Tanzania J Hlth Res

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Brugada syndrome is an autosomal-dominant arythmogenic genetic disorder associated with mutation in the SCN5A gene. We report a case of 3-month-old Tanzanian male who was admitted at Muhimbili National Hospital in Dar es Salaam, Tanzania with severe pneumonia, high fever and monomorphic ventricular tachycardia. The patient was treated with intravenous Amiodarone. In addition, oxygen, parenteral antibiotics, antipyretics and intravenous fluids were also given. About 2 hours and 20 minute later the child stabilized. An ECG obtained shortly after termination of ventricular tachycardia showed the typical J-point and coved ST elevation typical of Brugada type I pattern. To the best of our knowledge, this is the first paediatric case with Brugada-type ECG to be reported in Sub-Saharan Africa. This case emphasizes the need to increase awareness among clinicians of clinical and genetic arythmogenic disorders. Multiple ECGs during and after febrile disorders should be performed in children who exhibit extreme tachycardia or signs of cardiac failure.

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“…Many of these cases with ECGs consistent with BS lack an accompanying syncopal episode and are often discovered unintentionally with resolution of the Brugada morphology upon treatment of fever; thereby forgoing further management other than routine follow-up. [4][5][6][7][8][9][10] There are even fewer case reports demonstrating syncope in a patient with diagnosed BS requiring invasive management. 11 In this unique case, the patient presented with syncope while febrile with pharyngitis and had an ECG indicating the possibility for BS.…”

Section: Discussionmentioning

confidence: 99%