Brugada phenocopy or congenital Brugada syndrome in a patient with spontaneous pneumopericardium and pericarditis

Khmao, Pichmanil; Long, Vannak; Ku, No; Lim, Sivutha

doi:10.1002/joa3.12488

Cited by 2 publications

(1 citation statement)

References 5 publications

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“… 7 Once the aetiology is resolved, the BrP ECG pattern normalises. 26 Differentiating between BrP and BrS is challenging but important, not least because while the clinical implications of BrP remain uncertain, patients with BrS are at increased risk of SCD and may require an ICD. 27 …”

Section: Brugada Phenocopymentioning

confidence: 99%

Brugada syndrome: should we be screening patients before prescribing psychotropic medication?

Attard

Stanniland

Attard

et al. 2022

Therapeutic Advances in Psychopharmacology

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Brugada syndrome (BrS) presents with a characteristic electrocardiogram (ECG) and is associated with sudden cardiac death. Until now, prolongation of QTc interval and its association with Torsade de Pointe and possible fatal arrhythmia have been the focus of routine baseline ECGs before prescribing psychotropic medication. A semi-systematic literature review was conducted using PubMed. The terms ‘Brugada’, ‘Brugada Syndrome’ AND ‘psychotropic’ ‘antipsychotic’ ‘antidepressant’ ‘mood stabilisers’ ‘clozapine’ ‘Tricyclic Antidepressants’ ‘Lithium’ were searched. From a search that delivered over 200 articles, 82 articles were included. Those that included details around causative medication, doses of medication and where clear timeline on drug cause were included. Where clarification was needed, the manufacturer of the medication was contacted directly. Psychotropic medication can be associated with BrS, Brugada phenocopy or unmasking of BrS, in overdose or in normal doses. Our results include a table summarising a number of psychotropic overdoses that led to BrS unmasking. Routine screening for BrS in patients before prescribing psychotropic medication is a natural extension of the baseline ECG currently routinely done to rule out QTc prolongation. Psychiatrists need to invest in ensuring better skills in interpreting ECGs and work closer with cardiologists in interpreting ECGs.

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Section: Brugada Phenocopymentioning

confidence: 99%

Brugada syndrome: should we be screening patients before prescribing psychotropic medication?

Attard

Stanniland

Attard

et al. 2022

Therapeutic Advances in Psychopharmacology

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Brugada-Like Ecg Pattern and Tumors Involving Right Ventricular Outflow Tract - Case Series and Literature Review

Elikowski¹,

Fertała²,

Zawodna-Marszałek³

et al. 2023

Wiad Lek

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Mechanical heart compression, including that from mediastinal tumor, may cause Brugada-like ECG pattern. Such ECG pattern might also be observed in intracardiac tumor obstructing the right ventricular out"ow tract (RVOT). Eight cases with Brugada-like ECG and tumors involving RVOT have been described so far; 4 growing in the mediastinum (with one example of in"ammatory mass), 3 with intracardiac location, and 1 being an organized pericardial hematoma. The authors present other 3 cases of intracardiac metastatic tumors in RVOT and Brugada-like ECG pattern with coved ST-segment elevation in the right precordial leads. All patients had negative history of cardiovascular disease or familiar malignant arrhythmia occurrence. ECG were done routinely; none of the patients had chest pain or an increased level of cardiac troponins. In all patients, neoplastic disease was at advanced stage. A 76-year-old male, had a history of four neoplasms: bladder cancer was being treated with chemotherapy, while prostate, tongue, and lung cancers had been resected years ago and no signs of local relapse were found. A 78-year-old female, was diagnosed with colon cancer 1 month after an episode of venous thromboembolism. Six months after the resection of cancer, second focus of adenocarcinoma was found in the rectum. Third patient, a 65-year-old-male had undergone nephrectomy for renal cancer a year before cardiac metastasis diagnosis.

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Brugada phenocopy or congenital Brugada syndrome in a patient with spontaneous pneumopericardium and pericarditis

Cited by 2 publications

References 5 publications

Brugada syndrome: should we be screening patients before prescribing psychotropic medication?

Brugada syndrome: should we be screening patients before prescribing psychotropic medication?

Brugada-Like Ecg Pattern and Tumors Involving Right Ventricular Outflow Tract - Case Series and Literature Review

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