Brugada Phenotype and Prostate Cancer

Kusano, Kengo

doi:10.1253/circj.cj-08-0976

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Interestingly, males with Brugada syndrome manifested significantly higher testosterone levels than control males, 30 and males with Brugada-like ECG results were at an increased risk for prostate cancer. 31, 32 Our findings of a prominent ST elevation in males after puberty and of the lower ST level after androgen-deprivation therapy in lead V2 might support a significant association between Brugada syndrome and hypertestosteronemia.…”

Section: Effect Of Androgen Deprivation Therapy and Role Of Testostersupporting

confidence: 52%

Gender Differences in the ST Segment - Effect of Androgen-Deprivation Therapy and Possible Role of Testosterone -

Ezaki

Nakagawa

Taniguchi

et al. 2010

Circ J

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp ender differences in the incidence of various types of ventricular arrhythmias have been reported. Torsades de pointes associated with long QT syndrome is more common in females than males. 1,2 The higher incidence of Brugada syndrome in males than females 3-5 is associated with gender differences in the early phase of ventricular repolarization, that is, the greater transient outward potassium current (Ito)-mediated phase 1 notch in the right ventricular epicardium in males than females. 6 Early repolarization syndrome is characterized by a prominent J wave and by ST-segment elevation in the left precordial leads; it is most commonly seen in young males. 7 Although the mechanisms underlying early repolarization syndrome remain unknown, it has been suggested to share notable cellular and ionic similarities with Brugada syndrome. 7-10Studies on gender-related repolarization differences have focused on the duration of repolarization, such as the longer QT 11,12 and JT intervals 13 in females than in males. While these sex differences in ventricular repolarization are not observed before, they become obvious after puberty, suggesting an important effect of sex hormone. In contrast, gender differences have been reported in the configuration of the ST segment in healthy subjects. 11 Previous studies showed that after puberty, the J point amplitude is higher and the ST segment angle is steeper in males. 14,15 However, little is currently known about age-and gender-related differences in the ST levels in the different leads that represent the right and left ventricles.Androgen-deprivation therapy, 16,17 a neoadjuvant treatment for prostate cancer, might strongly inhibit the hormonal modulation of not only prostate cells but also of cardiac ventricular myocytes. Although this therapy is associated with increased risks of cardiovascular death in patients with prostate cancer, 18,19 its effects on ventricular repolarization including the ST segment remain to be elucidated.We studied healthy subjects to identify age-and gender differences in the ST segments in leads V2 and V5, which are Background: ST-segment elevation in a structurally normal heart is observed in Brugada- and early repolarization syndrome. The incidence of both syndromes is much higher in males than females. Clinical and basic studies suggest that testosterone plays an important role in ventricular repolarization.

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Section: Effect Of Androgen Deprivation Therapy and Role Of Testostersupporting

confidence: 52%

Gender Differences in the ST Segment - Effect of Androgen-Deprivation Therapy and Possible Role of Testosterone -

Ezaki

Nakagawa

Taniguchi

et al. 2010

Circ J

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Lipopolysaccharide Modifies Sodium Current Kinetics through ROS and PKC Signalling in Induced Pluripotent Stem-Derived Cardiomyocytes from Brugada Syndrome Patient

Liao

Fan

et al. 2022

JCDD

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Studies have suggested a connection between inflammation and arrhythmogenesis of Brugada syndrome (BrS). However, experimental studies regarding the roles of inflammation in the arrhythmogenesis of BrS and its underlying mechanism are still lacking. This study aimed to investigate the influence of inflammation on BrS-phenotype features using human-induced stem cell-derived cardiomyocytes (hiPSC-CMs) from a BrS-patient carrying an SCN10A variant (c.3749G > A). After LPS treatment, the peak sodium current decreased significantly in SCN10A-hiPSC-CMs, but not in healthy donor-hiPSC-CMs. LPS also changed sodium channel gating kinetics, including activation, inactivation, and recovery from inactivation. NAC (N-acetyl-l-cysteine), a blocker of ROS (reactive oxygen species), failed to affect the sodium current, but prevented the LPS-induced reduction of sodium channel currents and changes in gating kinetics, suggesting a contribution of ROS to the LPS effects. Hydrogen peroxide (H2O2), a main form of ROS in cells, mimicked the LPS effects on sodium channel currents and gating kinetics, implying that ROS might mediate LPS-effects on sodium channels. The effects of H2O2 could be attenuated by a PKC blocker chelerythrine, indicating that PKC is a downstream factor of ROS. This study demonstrated that LPS can exacerbate the loss-of-function of sodium channels in BrS cells. Inflammation may play an important role in the pathogenesis of BrS.

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Brugada Phenotype and Prostate Cancer

Cited by 2 publications

References 9 publications

Gender Differences in the ST Segment - Effect of Androgen-Deprivation Therapy and Possible Role of Testosterone -

Gender Differences in the ST Segment - Effect of Androgen-Deprivation Therapy and Possible Role of Testosterone -

Lipopolysaccharide Modifies Sodium Current Kinetics through ROS and PKC Signalling in Induced Pluripotent Stem-Derived Cardiomyocytes from Brugada Syndrome Patient

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