2020
DOI: 10.1080/00015385.2020.1790823
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Brugada syndrome

Abstract: Brugada syndrome (BrS) is an inherited cardiac arrhythmia syndrome that causes a heightened risk for ventricular tachyarrhythmias and sudden cardiac death. BrS is characterised by a coved ST-segment elevation in right precordial leads. The prevalence is estimated to range between 1 in 5,000 to 1 in 2,000 in different populations, with the highest being in Southeast Asia and in males. More than 18 genes associated with BrS have been discovered and recent evidence has suggested a complex polygenic mode of inheri… Show more

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Cited by 12 publications
(19 citation statements)
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References 124 publications
(179 reference statements)
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“…Furthermore, men experience arrhythmic events at earlier ages and have more severe phenotypes [9]. The effect of sex hormones and differences in the expression of cardiac transmembrane channels are supposed to be responsible for gender differences in BrS [1,10]. Similarly, in this family, more men were affected (7 men versus 3 women).…”
Section: Discussionmentioning
confidence: 84%
See 2 more Smart Citations
“…Furthermore, men experience arrhythmic events at earlier ages and have more severe phenotypes [9]. The effect of sex hormones and differences in the expression of cardiac transmembrane channels are supposed to be responsible for gender differences in BrS [1,10]. Similarly, in this family, more men were affected (7 men versus 3 women).…”
Section: Discussionmentioning
confidence: 84%
“…Brugada Syndrome (BrS) is an inheritable cardiac channelopathy, mainly characterized by a particular electrocardiogram (ECG) pattern consisting of coved-typed J point elevations > 0.2 mV in ≥ 1 right precordial leads with T wave inversions in the absence of cardiac structural abnormalities [1]. Patients with BrS are more amenable to ventricular arrhythmia/fibrillation (VA/VF) and sudden cardiac death (SCD).…”
Section: Introductionmentioning
confidence: 99%
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“…According to this theory, epicardial dispersion of repolarization results in certain epicardial sites undergoing all-or-nothing repolarization at the end of Phase 1 of the cardiac action potential (Sieira et al, 2016). Heterogeneous repolarization is known to lead to Phase II reentry, which involves the occurrence of premature extrasystolic beats that are capable of initiating VT or VF (Korlipara, Korlipara, & Pentyala, 2020; Tse, 2016).…”
Section: Pathophysiologymentioning
confidence: 99%
“…Even in people with a similar ECG pattern of brugada the symptoms can vary from dizziness, fainting, shortness of breath, palpitations, and seizures to even some people being completely asymptomatic with the diagnosis of brugada being only an incidental ECG finding (7). Furthermore, it has come to light recently that brugada pattern can sometimes be unmasked in individuals who have inherited the disorder because of other conditions such a fever, injuries, COVID and other viral illnesses, stress and even certain medications and anesthetic agents (8).…”
Section: Introductionmentioning
confidence: 99%