Brugada syndrome unmasked by dengue fever

Abstract

Key Clinical MessageUnderstanding the circumstances, leading to unmasking of hidden Brugada syndrome is essential for the practicing clinician and the patients so that they are informed adequately to seek prompt medical attention.AbstractBrugada syndrome is a genetic arrhythmia syndrome characterized by a coved type of ST‐segment elevation in the ECG. The patients are usually asymptomatic, with unmasking of the disease under certain conditions. We are reporting the case of a patient diagnosed with Brugada syndrome, which was unmasked during an attack of dengue fever.

Primary Electrical Heart Disease—Principles of Pathophysiology and Genetics

“…The ECG findings suggested BrS type-1, unmasked by dengue fever. This case illustrates that febrile illnesses, such us dengue fever, can reveal the presence of BrS in patients [122]. The results of studies proving a positive treatment effect in BrS patients are limited.…”

“…A score of 2-3 suggests a potential diagnosis of BrS, while a score of ≥3.5 confirms a definite diagnosis. The criteria and points assigned are shown in the Table 6 [122,123]. Family history-only award points once for the highest score within this category (a) First-or second-degree relative with definite BrS 2 (b) Suspicious SCD (fever, nocturnal, Brugada aggravating drugs) in a first-or second-degree relative 1 (c) Unexplained SCD <45 years in first-or second-degree relative with negative autopsy 0.5 3.…”

“…Moreover, it is essential to promptly address fever by using antipyretic medications [124]. In connection with the latter, Sivanandam et al [122] described a noteworthy case of a patient hospitalized for intermittent fever associated with a non-productive cough. He did not have a background of fainting, irregular heartbeats, chest discomfort, difficulty breathing, or any other cardiovascular or pulmonary symptoms.…”

“…A score of 2-3 suggests a potential diagnosis of BrS, while a score of ≥3.5 confirms a definite diagnosis. The criteria and points assigned are shown in the Table 6[122,123].…”