Bruising and bleeding in infants and children – a practical approach

Khair, Kate; Liesner, Ri

doi:10.1111/j.1365-2141.2006.06016.x

Cited by 73 publications

(61 citation statements)

References 85 publications

(98 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…63 Likewise, PT and APTT are simultaneously prolonged in conditions that involve deficiencies spanning all 3 pathways, such as VKCFD. 31,64 Because fibrin generation is not affected in FXIII deficiency, PT and APTT are normal in this RBD. 61 Consultation with a hematologist is recommended to assist with interpretation STATE-OF-THE-ART REVIEW ARTICLE of laboratory results, facilitate further definitive testing, and ensure that confirmatory laboratory assays are performed properly.…”

Section: Diagnostic Evaluation and Considerationsmentioning

confidence: 99%

“…The results of routine coagulation studies can be used to narrow down the possible disorders (Fig 1, Table 3). [61][62][63][64][65] In isolation, the PT and APTT, respectively, assess the integrity of the extrinsic and intrinsic pathways of the coagulation cascade. 63 Together, PTand APTTassess the integrity of the final common pathway of the coagulation cascade.…”

Section: Diagnostic Evaluation and Considerationsmentioning

confidence: 99%

See 1 more Smart Citation

Rare Bleeding Disorders in Children: Identification and Primary Care Management

Acharya

2013

Pediatrics

View full text Add to dashboard Cite

Bleeding symptoms are common in healthy children but occasionally may indicate an underlying congenital or acquired bleeding diathesis. The rare bleeding disorders (RBDs) comprise inherited deficiencies of coagulation factors I (congenital fibrinogen deficiencies), II, V, VII, X, XI, and XIII and combined factor deficiencies, most notably of factors V and VIII and of vitamin K-dependent factors. These disorders often manifest during childhood and may present with recurrent or even serious or life-threatening bleeding episodes, particularly during the neonatal period. Accordingly, primary care and other nonhematologist pediatric providers should be familiar with the clinical presentation and initial evaluation of these rare disorders. Bleeding manifestations generally vary within the same RBD and may be indistinguishable from 1 RBD to another or from other more common bleeding disorders. Serious bleeding events such as intracranial hemorrhage may be heralded by less serious bleeding symptoms. The results of initial coagulation studies, especially prothrombin time and activated partial thromboplastin time, are often helpful in narrowing down the potential factor deficiency, with factor XIII deficiency being an exception. Consultation with a hematologist is advised to facilitate accurate diagnosis and to ensure proper management and follow-up. The approach to bleeding episodes and invasive procedures is individualized and depends on the severity, frequency, and, in the case of procedures, likelihood of bleeding. Prophylaxis may be appropriate in children with recurrent serious bleeding and specifically after life-threatening bleeding episodes. When available, specific purified plasma-derived or recombinant factor concentrates, rather than fresh frozen plasma or cryoprecipitate, are the treatment of choice. Pediatrics 2013;132:882-892

show abstract

Section: Diagnostic Evaluation and Considerationsmentioning

confidence: 99%

Section: Diagnostic Evaluation and Considerationsmentioning

confidence: 99%

Rare Bleeding Disorders in Children: Identification and Primary Care Management

Acharya

2013

Pediatrics

View full text Add to dashboard Cite

show abstract

“…In addition inherited or acquired causes of bleeding may present in the neonatal period or early infancy [1]. Hemostasis is an effective but complex process which requires integration of various coagulation factors along with vessel wall integrity.…”

Section: Introductionmentioning

confidence: 99%

Intracerebral Bleeding in Young Infants due to Rare Etiologies–A Report of two Cases

Tewari¹,

Tewari²

2016

J Neonatal Biol

View full text Add to dashboard Cite

Neonates and young infants are physiologically encumbered by an inadequate hemostatic mechanism. They may also have inherited or acquired bleeding disorders which may have a catastrophic presentation with intracerebral hemorrhage. The need to reach an accurate diagnosis is paramount in order to provide accurate therapy and genetic counseling. We report two infants who presented with unprovoked life threatening massive intracerebral hemorrhage. The first infant was diagnosed and managed for congenital factor V deficiency while the second infant had Glanzmann thrombasthenia.

show abstract

“…(27,29,30) Coagulation disorders, whether acquired or inherited, need to be considered when evaluating bruises. (31) In the context of possible child maltreatment, it is important for the clinician to be able to differentiate between bruising caused by minimal (or no) recognized trauma but related to an underlying medical predisposition, • Bruises on the ears, neck, feet, buttocks or torso (torso includes chest, back, abdomen, genitalia)…”

Section: Bruises From a Hematological Or Othermentioning

confidence: 99%

The medical assessment of bruising in suspected child maltreatment cases: A clinical perspective

Michelle¹,

Amy²,

Anne³

et al. 2013

Paediatrics &Amp; Child Health

View full text Add to dashboard Cite

The recommendations in this document do not indicate an exclusive course of treatment or procedure to be followed. Variations, taking into account individual circumstances, may be appropriate. All Canadian Paediatric Society position statements and practice points are reviewed on a regular basis. Retired statements are removed from the website. Please consult the Position Statements section of the CPS website (www.cps.ca) for the full-text, current version.

show abstract

Bruising and bleeding in infants and children – a practical approach

Cited by 73 publications

References 85 publications

Rare Bleeding Disorders in Children: Identification and Primary Care Management

Rare Bleeding Disorders in Children: Identification and Primary Care Management

Intracerebral Bleeding in Young Infants due to Rare Etiologies–A Report of two Cases

The medical assessment of bruising in suspected child maltreatment cases: A clinical perspective

Contact Info

Product

Resources

About