Brûlure néonatale accidentelle à l'isopropanol

Brayer, C; Micheau, P; Bony, C.; Tauzin, Laurent; Pilorget, H; Sampériz, Sylvain; Alessandri, J.L.

doi:10.1016/j.arcped.2004.04.023

Cited by 13 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Severe burns and even death can be caused by the alcohol content and especially because the skin is thin. 4 The content of 4-5% acetic acid causes burns of the skin and esophagus in newborn infants and children. When these chemicals are examined, these burns are seen to have the same characteristics as acid burns.…”

Section: Discussionmentioning

confidence: 99%

<p>Rare chemical burns: first response, early hospitalization and first treatment: retrospective analysis from a single center</p>

Akelma¹,

Karahan²,

Kılıç³

2019

CWCMR

View full text Add to dashboard Cite

Background: Chemical burns are common enough not to be underestimated and may cause significant physical, psychological and economic burdens in poor and rural areas. The most important point in the evaluation and management of such injuries is to identify the chemical substance, to be informed about the damage to be done and to make the first provision. Objective: The objective of this study was to evaluate the outcomes of chemical burns and clinical variables of chemical burns. Methods: A retrospective analysis was performed on all patients admitted between 2014 and 2018, at our burn unit of our hospital due to chemical burns. The patients were evaluated with respect to demographic aspects, type of chemicals, burn percentage, burn level, burn site, length of hospital stay, first application type, hospitalization day, presence of additional pathology and treatment. Results: Twelve patients were male and six were female. The patients were hospitalized after the burns, 6 of them on the 1st day, 6 on the 2nd day, 4 on the 5th day, 1 on the 10th day and 1 on the 14th day of the burn (3,44±3,53 days). The mean hospital stay was 5.5 days. Chemical burn types consisted of cement (n=3), superglue (n=2), air bag gas (n=2), liquid oxygen (n=2), sink opener (n=3), nail polish remover (n=2), expigment cream (n=1), hot tar (n=1), IL-33 solution (n=1), white vinegar (n=1) and fridge gas (n=1). Discussion and Conclusion: Chemical burn injuries are an important part of total burn injuries. They can be largely preventable and if managed properly can have a good outcome.

show abstract

Section: Discussionmentioning

confidence: 99%

<p>Rare chemical burns: first response, early hospitalization and first treatment: retrospective analysis from a single center</p>

Akelma¹,

Karahan²,

Kılıç³

2019

CWCMR

View full text Add to dashboard Cite

show abstract

“…Because of this neonatal toxicity, isopropyl alcohol is excluded from antiseptics used for neonates, but it remains widely used in house cleaning and other products. Tragically, a neonatal death from a skin burn caused by his mother using a disposable antiseptic wipe has recently been reported (Brayer et al, 2004) and highlights the difficulties in selecting safe solvents for skin ranging from neonates to adults, in both health and disease.…”

Section: Alcoholsmentioning

confidence: 99%

Pharmaceutical Solvents as Vehicles for Topical Dosage Forms

Williams

Biotechnology: Pharmaceutical Aspects

View full text Add to dashboard Cite

“…corticosteroids (Borzyskowski et al, 1976;Munro, 1976) and chlorhexidine (Cowen et al, 1979). Application of antiseptic solutions containing alcohols has led to severe burns in premature infants (Brayer et al, 2004). Pulmonary, sublingual, and buccal absorption are not well studied in preterm or term neonates (O'Hara et al, 2015;van den Anker and Allegaert, 2021).…”

Section: Absorptionmentioning

confidence: 99%

The Blind Spot of Pharmacology: A Scoping Review of Drug Metabolism in Prematurely Born Children

et al. 2022

View full text Add to dashboard Cite

The limit for possible survival after extremely preterm birth has steadily improved and consequently, more premature neonates with increasingly lower gestational age at birth now require care. This specialized care often include intensive pharmacological treatment, yet there is currently insufficient knowledge of gestational age dependent differences in drug metabolism. This potentially puts the preterm neonates at risk of receiving sub-optimal drug doses with a subsequent increased risk of adverse or insufficient drug effects, and often pediatricians are forced to prescribe medication as off-label or even off-science. In this review, we present some of the particularities of drug disposition and metabolism in preterm neonates. We highlight the challenges in pharmacometrics studies on hepatic drug metabolism in preterm and particularly extremely (less than 28 weeks of gestation) preterm neonates by conducting a scoping review of published literature. We find that >40% of included studies failed to report a clear distinction between term and preterm children in the presentation of results making direct interpretation for preterm neonates difficult. We present summarized findings of pharmacokinetic studies done on the major CYP sub-systems, but formal meta analyses were not possible due the overall heterogeneous approaches to measuring the phase I and II pathways metabolism in preterm neonates, often with use of opportunistic sampling. We find this to be a testament to the practical and ethical challenges in measuring pharmacokinetic activity in preterm neonates. The future calls for optimized designs in pharmacometrics studies, including PK/PD modeling-methods and other sample reducing techniques. Future studies should also preferably be a collaboration between neonatologists and clinical pharmacologists.

show abstract

Brûlure néonatale accidentelle à l'isopropanol

Cited by 13 publications

References 11 publications

<p>Rare chemical burns: first response, early hospitalization and first treatment: retrospective analysis from a single center</p>

<p>Rare chemical burns: first response, early hospitalization and first treatment: retrospective analysis from a single center</p>

Pharmaceutical Solvents as Vehicles for Topical Dosage Forms

The Blind Spot of Pharmacology: A Scoping Review of Drug Metabolism in Prematurely Born Children

Contact Info

Product

Resources

About