Brunner's Glands: A Structural,Histochemical and Pathological Profile

Krause, William J.

doi:10.1016/s0079-6336(00)80006-6

Cited by 123 publications

(91 citation statements)

References 326 publications

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“…The authors suggest that this could compensate for alterations in fatty acid absorption in the small intestine. It has also been demonstrated that the mucin present in the lumen of the digestive tract are able to bind fatty acids and that these could act as a shield against oxygen radicals ( 48,49 ). Note that in our study C20:4 (supplementary Figs.…”

Section: Discussionsupporting

confidence: 62%

Lipid mapping of colonic mucosa by cluster TOF-SIMS imaging and multivariate analysis in cftr knockout mice

Brulet

Seyer

Edelman

et al. 2010

Journal of Lipid Research

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Section: Discussionsupporting

confidence: 62%

Lipid mapping of colonic mucosa by cluster TOF-SIMS imaging and multivariate analysis in cftr knockout mice

Brulet

Seyer

Edelman

et al. 2010

Journal of Lipid Research

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“…Hence, the cells physiologically mediating bicarbonate secretion may not be the same as those examined to assess cytoprotection. However, there is no compelling evidence that bicarbonate secretion is restricted (or even localized) to Brunner's glands, structures that may play a greater role in secretion of mucin and bioactive peptides (13). Most relevant to this study, initial in situ hybridization studies localized CFTR mRNA exclusively to crypts in human duodenum (14).…”

Section: Is Intracellular Ph More Important Than Extracellular Ph?mentioning

confidence: 93%

Choosing sides in the battle against gastric acid

Montrose

2001

J. Clin. Invest.

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“…Trefoil peptides are involved in the oligomerization process of the mucin glycoprotein molecules (Krause, 2000), and this assists the formation of the protective barrier on the luminal side of the intestine.…”

Section: Brunner's Gland Functionmentioning

confidence: 99%

“…We now know its secretion has many more components than originally discovered and these have numerous functions important for intestinal homeostasis, as it creates an environment that is ideal for intestinal enzyme efficiency (Krause, 2000).…”

Section: Brunner's Gland Functionmentioning

confidence: 99%

Insights into the Development of Gastrointestinal Brunner's Glands: Critical Stem Cells and Differentiation Factors

Parappilly¹,

Marín²,

Lo³

et al. 2017

Gastroenterology

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Gastrointestinal Brunner's Glands are composed of secretory glandular epithelium and are located at the junction between the pylorus of the stomach and the duodenum of the small intestine. Brunner's Glands function by secreting a mucous-rich substance containing sodium bicarbonate and other important proteins in order to neutralize stomach acid and prevent damage to the intestinal epithelium. Prior research has shown that Brunner's Glands develop after birth, but little is known about the molecular mechanisms that control their development. Tumors of the in Brunner's Glands are known to occur in humans and understanding their developmei:it may assist in understanding how cancer and other pathologies in this gland arises. The aim of this study is to evaluate the stem cells and proteins that contribute to the development of the gland by using the laboratory mouse as our model organism.A stem cell marker known as Lrig I is a regulator of intestinal stem cell development and by using a technique known as "developmental lineage tracing," we have shown that Lrigl expressing stem cells contribute to the development of the Brunner's Gland. Developmental lineage tracing was also used in order to test for the ii iii contribution of Villin to the formation of the Brunner's Gland, and this is another intestinal marker important for differentiation. Our results showed that Brunner's Glands do not express Villin. In addition, since Brunner's Glands are secretory glands, we hypothesized that a transcription factor called SPDEF is critical for proper development as it is an important protein for secretory gland formation. By analyzing the small intestines of transgenic mice with SPDEF mutations at multiple stages of maturity, we find that Brunner's Glands were largely deformed and underdeveloped.These findings suggest that Brunner's Glands are more closely related to the gastric epithelium, rather than the intestinal epithelium as has been previously postulated. Overall, the results of this study provide insight into the specific progenitor cells that contribute developmentally to the Brunner's Gland, and shed light on the molecular mechanisms important for proper formation.

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Brunner's Glands: A Structural,Histochemical and Pathological Profile

Cited by 123 publications

References 326 publications

Lipid mapping of colonic mucosa by cluster TOF-SIMS imaging and multivariate analysis in cftr knockout mice

Lipid mapping of colonic mucosa by cluster TOF-SIMS imaging and multivariate analysis in cftr knockout mice

Choosing sides in the battle against gastric acid

Insights into the Development of Gastrointestinal Brunner's Glands: Critical Stem Cells and Differentiation Factors

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