BS56 An epigenomic investigation of atrial fibrillation in a paired left and right atrial cohort

Abstract

vasodilator, but would not compromise blood pressure or myocardial contractility. Aims We investigated i) The vasodilatory properties of Chroman 1 (Ch1) (a selective ROCK 2 inhibitor), relative to Fasudil, to ascertain whether this agent could demonstrate effective vasorelaxation and ii) Performed a dose response experiment using a rat model in-vivo, to test the effects of Ch1 on myocardial contractility and left ventricular ejection fraction (LVEF %), mean arterial pressure (MAP) and heart rate. Methods Thoracic aorta of male SD rats was dissected and 3mm segments were suspended into a tissue bath. These vascular rings were pre-constricted with 1µM PE and treated with [