BSA-modified poly(pyrrole-3-carboxylic acid) nanoparticles as carriers for combined chemo-photothermal therapy

Abstract

Homogenous poly(pyrrole-3-carboxylic acid) nanoparticles with high near-infrared absorption and abundant functional groups were fabricated using a facile reverse microemulsion method.

PPy nanoneedle based nanoplatform capable of overcoming biological barriers for synergistic chemo-photothermal therapy

“…1C showed PPy nanoneedles showed a strong absorption in NIR region. These results were in agreement with previous reports, [15][16][17] suggesting the potential photothermal agent of PPy. In addition, PPy-HA@DOX also displayed the typical absorption peak of DOX at 480 nm, further revealing the DOX loading (17.2%, mass ratio).…”

“…By contrast, the organic conductive polymers, polypyrrole (PPy) nanoparticles, were an increasingly recognized alternative due to their excellent biocompatibility and photostability. [15][16][17] Besides, compared with most PTT agents, PPy NPs have higher photothermal conversion efficiency due to strong NIR absorbance. 18 Notwithstanding their potential, PPy nanoparticles faced a serious of biological barriers such as mononuclear phagocyte system, hemorheological ow limitations and endothelial extravasation, cellular internalization, nuclear drug delivery, and multidrug resistance, which limited the site-specic bioavailability and impeded therapeutic efficacy.…”

Progress of Phototherapy Applications in the Treatment of Bone Cancer

“…Conductive polymers are promising for clinical PTAs as they are cost-efficient and their structures can be precisely controlled [ 204 , 323 , 324 ]. They are usually used as coatings or crosslinkers to modify scaffolds or nanoparticles, leading to materials with multifunction [ 324 , 325 ]. PDA is the most widely used conductive polymer in PTT [ 326 , 327 , 328 ].…”

NIR‐Responsive Fe3O4@MSN@PPy‐PVP Nanoparticles as the Nano‐Enzyme for Potential Tumor Therapy

“…Mesoporous nanomaterials have been widely used in the biomedical industry for their low toxicity, adjustable pore size, large specific surface area, and easy surface modification [10] . Among many organic photothermal conversion materials, polypyrrole (PPy) nanoparticles have attracted much attention because they have a good biocompatibility and can convert the near‐infrared (NIR) light into thermal energy [5a,6d,11] . Nevertheless, the polymerization ability of pyrrole at α and β sites makes it difficult to form ordered structures like spheres or nanotubes, which limits the biological application [12] .…”