Bovine Spongiform Encephalopathy (BSE), also referred to as Mad Cow Disease, has become a significant public health issue with significant consequences for both society and the economy. This study examines the social and economic consequences of BSE (bovine spongiform encephalopathy) and studies its potential to be transmitted to humans. It addresses the complex network of relationships between human health, agriculture, and the environment. The socio-economic research examines the impact of BSE outbreaks on the agricultural sector, including the substantial financial losses experienced by farmers, the meat industry, and associated businesses. Moreover, this study investigates the widespread impact on international trade, consumer choices, and public trust in food safety, highlighting the importance of efficient risk communication and crisis management measures. This research examines the possible transmission of BSE from animals to people, with a specific focus on the zoonotic perspective. Gaining knowledge on the processes of zoonotic transmission is essential in order to effectively prevent the occurrence of novel human prion disorders. This study examines the scientific information on how BSE can be transmitted and evaluates the dangers and uncertainties connected with BSE as a zoonotic concern. In conclusion, this comprehensive analysis provides insights into the complex interplay between BSE, public health, and socio-economic factors. The findings contribute to a better understanding of the challenges posed by BSE and offer valuable information for policymakers, health professionals, and stakeholders involved in managing the impact of zoonotic diseases on both human health and the broader societal landscape.