BSHXF-medicated serum combined with ADSCs regulates the TGF-β1/Smad pathway to repair oxidatively damaged NPCs and its component analysis

Duan, Jiahao; Li, Zhaoyong; Liu, Enxu; Long, Hong‐Ping; Chen, Long; Yang, Shaofeng

doi:10.1016/j.jep.2023.116692

Cited by 7 publications

(2 citation statements)

References 33 publications

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“…BuShenHuoXueFang (BSHXF) is a Chinese herbal formula that has been reported to improve the environment of degenerated IVD, enhance NPC proliferation, and delay IDD progression [139]. Therefore, the role of BSHXF-medicated serum in MSC differentiation was examined, and ADMSCs exhibited differentiation toward an NPC-like phenotype [140].…”

Section: Molecules-exogenous Factorsmentioning

confidence: 99%

A Review: Methodologies to Promote the Differentiation of Mesenchymal Stem Cells for the Regeneration of Intervertebral Disc Cells Following Intervertebral Disc Degeneration

Ohnishi,

Homan,

Fukushima

et al. 2023

Cells

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Intervertebral disc (IVD) degeneration (IDD), a highly prevalent pathological condition worldwide, is widely associated with back pain. Treatments available compensate for the impaired function of the degenerated IVD but typically have incomplete resolutions because of their adverse complications. Therefore, fundamental regenerative treatments need exploration. Mesenchymal stem cell (MSC) therapy has been recognized as a mainstream research objective by the World Health Organization and was consequently studied by various research groups. Implanted MSCs exert anti-inflammatory, anti-apoptotic, and anti-pyroptotic effects and promote extracellular component production, as well as differentiation into IVD cells themselves. Hence, the ultimate goal of MSC therapy is to recover IVD cells and consequently regenerate the extracellular matrix of degenerated IVDs. Notably, in addition to MSC implantation, healthy nucleus pulposus (NP) cells (NPCs) have been implanted to regenerate NP, which is currently undergoing clinical trials. NPC-derived exosomes have been investigated for their ability to differentiate MSCs from NPC-like phenotypes. A stable and economical source of IVD cells may include allogeneic MSCs from the cell bank for differentiation into IVD cells. Therefore, multiple alternative therapeutic options should be considered if a refined protocol for the differentiation of MSCs into IVD cells is established. In this study, we comprehensively reviewed the molecules, scaffolds, and environmental factors that facilitate the differentiation of MSCs into IVD cells for regenerative therapies for IDD.

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Section: Molecules-exogenous Factorsmentioning

confidence: 99%

A Review: Methodologies to Promote the Differentiation of Mesenchymal Stem Cells for the Regeneration of Intervertebral Disc Cells Following Intervertebral Disc Degeneration

Ohnishi,

Homan,

Fukushima

et al. 2023

Cells

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“…For example, one study showed that Bushen Huoxue Recipe can promote the conversion of adipose stem cells (ADSCs) to NPCs by regulating the TGF-β1/Smad pathway, which can promote the growth and proliferation of NPCs, delay aging, improve the microenvironment, and repair oxidatively damaged NPCs. 80 Duhuo Jisheng Decoction (DHJSD) effectively attenuates LPS-induced disc inflammatory response and further inhibits NLRP3 expression, which may inhibit NPC pyroptosis via the SDF-1/CXCR4-NF-kB-NLRP3 axis. 81 Research into cell therapy is an important modality in the treatment of IDD.…”

Section: Therapeutic Role Of Immune Cells In Iddmentioning

confidence: 99%

Analysis of global research hotspots and trends in immune cells in intervertebral disc degeneration: A bibliometric study

Wang,

Mi,

Chen

et al. 2023

Human Vaccines & Immunotherapeutics

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Intervertebral disc degeneration is an important pathological basis for spinal degenerative diseases. The imbalance of the immune microenvironment and the involvement of immune cells has been shown to lead to nucleus pulposus cells death. This article presents a bibliometric analysis of studies on immune cells in IDD in order to clarify the current status and hotspots. We searched the WOSCC, Scopus and PubMed databases from 01/01/2001 to 08/03/2023. We analyzed and visualized the content using software such as Citespace, Vosviewer and the bibliometrix. This study found that the number of annual publications is increasing year on year. The journal study found that Spine had the highest number of articles and citations. The country/regions analysis showed that China had the highest number of publications, the USA had the highest number of citations and total link strength. The institutional analysis found that Shanghai Jiao Tong University and Huazhong University of Science Technology had the highest number of publications, Tokai University had the highest citations, and the University of Bern had the highest total link strength. Sakai D and Risbud MV had the highest number of publications. Sakai D had the highest total link strength, and Risbud MV had the highest number of citations. The results of the keyword analysis suggested that the current research hotspots and future directions continue to be the study of the mechanisms of immune cells in IDD, the therapeutic role of immune cells in IDD and the role of immune cells in tissue engineering for IDD.

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Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration

Wang,

Rong,

Xie

et al. 2024

Experimental Gerontology

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BSHXF-medicated serum combined with ADSCs regulates the TGF-β1/Smad pathway to repair oxidatively damaged NPCs and its component analysis

Cited by 7 publications

References 33 publications

A Review: Methodologies to Promote the Differentiation of Mesenchymal Stem Cells for the Regeneration of Intervertebral Disc Cells Following Intervertebral Disc Degeneration

A Review: Methodologies to Promote the Differentiation of Mesenchymal Stem Cells for the Regeneration of Intervertebral Disc Cells Following Intervertebral Disc Degeneration

Analysis of global research hotspots and trends in immune cells in intervertebral disc degeneration: A bibliometric study

Visualizing the bibliometrics of the inflammatory mechanisms in intervertebral disc degeneration

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