Bta-miR-493 Inhibits Bovine Preadipocytes Differentiation by Targeting BMPR1A via the TGFβ/BMP and p38MAPK Signaling Pathways

Feng, Lei; Wang, Xiaoyu; Yuan, Wei; Zhang, Ziyi; Zhang, Wenzhen; Zan, Linsen; Cheng, Gong

doi:10.1021/acs.jafc.2c05719

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…Similarly, Huang et al reported that the knockdown of SMAD4 disrupts the BMP2/4-induced adipogenic commitment process in the same cellular model . Long et al demonstrated that inhibition of upstream components, such as BMPR1 promotes preadipocyte proliferation but inhibits their differentiation in a culture of bovine preadipocytes …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…41 Long et al demonstrated that inhibition of upstream components, such as BMPR1 promotes preadipocyte proliferation but inhibits their differentiation in a culture of bovine preadipocytes. 42 In addition, the ata-miR166b-5p potentially targets SMAD3, a multifaceted regulator in adipose physiology and the pathogenesis of obesity and type 2 diabetes mediated by the TGF-β1/SMAD3 signaling. 43 In vivo studies have suggested that blocking the TGF-β1/SMAD3 signaling represents a holistic approach to treating metabolic syndrome factors since it may protect from obesity, diabetes, and hepatic steatosis.…”

Section: Carrot Micrornas Could Influence Human Lipid Metabolismmentioning

confidence: 99%

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Targeting Metabolic Syndrome Pathways: Carrot microRNAs As Potential Modulators

Reza-Zaldívar,

Jacobo-Velázquez

2024

ACS Omega

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Metabolic syndrome is a condition characterized by metabolic alterations that culminate in chronic noncommunicable diseases of high morbidity and mortality, such as cardiovascular diseases, type 2 diabetes, nonalcoholic fatty liver disease, and colon cancer. Developing new therapeutic strategies with a multifactorial approach is important since current therapies focus on only one or two components of the metabolic syndrome. In this sense, plant-based gene regulation represents an innovative strategy to prevent or modulate human metabolic pathologies, including metabolic syndrome. Here, using a computational and systems biology approach, it was found that carrot microRNAs can modulate key BMPs/SMAD signaling members, C/EBPs, and KLFs involved in several aspects associated with metabolic syndrome, including the hsa04350:TGF-beta signaling pathway, hsa04931:insulin resistance, hsa04152:AMPK signaling pathway, hsa04933:AGE-RAGE signaling pathway in diabetic complications, hsa04010:MAPK signaling pathway, hsa04350:TGF-beta signaling pathway, hsa01522:endocrine resistance, and hsa04910:insulin signaling pathway. These data demonstrated the potential applications of carrot microRNAs as effective food-based therapeutics for obesity and associated metabolic diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Carrot Micrornas Could Influence Human Lipid Metabolismmentioning

confidence: 99%

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Targeting Metabolic Syndrome Pathways: Carrot microRNAs As Potential Modulators

Reza-Zaldívar,

Jacobo-Velázquez

2024

ACS Omega

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“…However, the low IMF content of yak meat has become a major bottleneck, restricting high-quality meat development in the yak industry. Recent studies report that non-coding RNAs (ncRNAs) regulate key aspects of lipid metabolism [ 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

miR-129 Regulates Yak Intramuscular Preadipocyte Proliferation and Differentiation through the PI3K/AKT Pathway

Qin,

Wang,

Zhong

et al. 2024

IJMS

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miR-129 plays a crucial role in regulating various cellular processes, including adipogenesis; however, its downstream molecular mechanisms remain unclear. In this study, we demonstrated that miR-129 promotes yak adipogenesis in vitro via the PI3K/AKT pathway. Overexpression and interference of miR-129 in yak intramuscular preadipocytes (YIMAs) enhanced and inhibited cell differentiation, respectively, with corresponding changes in cell proliferation. Further investigation revealed that miR-129 enhances AKT and p-AKT activity in the AKT pathway without affecting cell apoptosis, and a specific inhibitor (LY294002) was used to confirm that miR-129 regulates YIMAs proliferation and differentiation through the PI3K/AKT pathway. Our findings suggest that miR-129 promotes yak adipogenesis by enhancing PI3K/AKT pathway activity. This study provides the foundation to precisely elucidate the molecular mechanism of miR-129 in YIMAs adipogenesis and develop advanced miRNA-based strategies to improve meat nutrition and obesity-related ailments in beef production.

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Emerging Materials in Cultivated Meat: Engineering Sustainable Food Solutions – A Review

Wang,

Li,

et al. 2024

Adv Funct Materials

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As the global population grows, the demand for protein‐enriched foods like meats is rising rapidly. Traditional farming practices face challenges including animal welfare, waste management, and carbon emissions, harming the environment. Consequently, meat substitutes have emerged as a promising area of research and as an alternative to traditional livestock‐sourced meats. Cultivated meat, produced through cell culture techniques, is a key area in cellular agriculture and offers a safe and well‐controlled production process for such future foods. The manufacturing of cultivated meat involves several disciplines, including cell culture, media optimization, scaffold design, and advanced manufacturing, along with nutrition, taste and safety topics to meet consumer acceptance and regulatory approvals. Although several review articles have addressed various aspects of cultivated meat, they tend to focus on specific domains rather than a comprehensive analysis of this transformative technology. This review highlights innovative and applied research findings in the field of cultivated meat, with a focus on critical aspects such as nutrition, cells, materials, and scaffold manufacturing technologies. Furthermore, the socio‐political and economic impacts of cultivated meat are explored, and practical recommendations for low‐cost and large‐scale production. Finally, the review also addresses existing challenges and outlines future directions for the development of cultivated meat.

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Bta-miR-493 Inhibits Bovine Preadipocytes Differentiation by Targeting BMPR1A via the TGFβ/BMP and p38MAPK Signaling Pathways

Cited by 6 publications

References 33 publications

Targeting Metabolic Syndrome Pathways: Carrot microRNAs As Potential Modulators

Targeting Metabolic Syndrome Pathways: Carrot microRNAs As Potential Modulators

miR-129 Regulates Yak Intramuscular Preadipocyte Proliferation and Differentiation through the PI3K/AKT Pathway

Emerging Materials in Cultivated Meat: Engineering Sustainable Food Solutions – A Review

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