BTG2TIS21/PC3 induces neuronal differentiation and prevents apoptosis of terminally differentiated PC12 cells

el-Ghissassi, Fatiha; Valsesia‐Wittmann, Sandrine; Falette, Nicole; Duriez, Cyril; Walden, Paul D.; Puisieux, Alain

doi:10.1038/sj.onc.1205888

Cited by 68 publications

(64 citation statements)

References 29 publications

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“…TIS21 /BTG2/PC3 , a transcriptional co-regulator, interacts with CAF1 protein (Rouault et al 1998;Prevot et al 2001) and works as a coactivator of ERa-mediated transcription with CCR4 and hCAF1 (Morel et al 2003), and reviewed by Duriez et al (2004). The role of TIS21 /BTG2/PC3 for neurite outgrowth of PC12 cells (Rouault et al 1996;Cortes et al 2000;Guardavaccaro et al 2000;Tirone 2001) and its importance for differentiation of neuronal stem cells have extensively been studied in mouse ventricular epithelium (Calegari et al 2002(Calegari et al , 2005Canzoniere et al 2004;Corrente et al 2002;el-Ghissassi et al 2002;Iacopetti et al 1999;Kosodo et al 2004;Haubensak et al 2004). Recently, the regulatory role of TIS21 /BTG2/PC3 in stage-specific expansion of thymocyte (Konrad and Zuniga-Pflucker 2005) and its role as a negative regulator in hematopoietic progenitor expansion (Oswald et al 2005) have also been reported.…”

Section: Potential Roles Of Tis21 /Btg2/pc3mentioning

confidence: 99%

TIS21 /BTG2/PC3 as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule

Lim

2006

J Cancer Res Clin Oncol

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TIS21/BTG2/PC3 , orthologs of mouse, human and rat, respectively, is initially identified as one of the early growth response genes and induced by various stimulations. TIS21 belongs to antiproliferative (APRO) gene family containing the BTG-Box A (Y 50 -N 71 ) and BTG-Box B (L 97 -E 115 ), which are highly conserved among various species. On the other hand, it has lately been found that the expression of TIS21 is constitutive and high in thymus, lung alveolar epithelium, proximal tubule of kidney and basal cell layer of prostate acini. Potential roles of TIS21 have been suggested as transcriptional co-regulator, differentiation and antiapoptotic factor in neurogenesis, key mediator of the stagespecific expansion of thymocyte and negative regulator of hematopoietic progenitor expansion, and tumor suppressor gene in both mouse and human. In addition, as pan-cell cycle regulator TIS21 induces G1/S arrest by pRB dependently and pRB independently and G2/M arrest and cell death in the p53 null tumor cells, and regulates the development of vertebrate patterning in mouse, paraxial mesoderm development in zebrafish, and notochord development in Xenopus. It has been known that the expression of TIS21 depends on the induction of wt p53 when cells are damaged, however, it can also be upregulated p53 independently by the activation of PKC-d pathway in tumor cells. The characteristic roles of TIS21 are discussed in the present review: (1) TIS21 inhibits early phase of carcinogenesis in its high expressers such as kidney, prostate, breast and thymus: Loss of constitutive and high expression of TIS21 was observed in the precancerous lesions as well as tumor tissues. As an endogenous cell death molecule, TIS21 may be involved in translocation of Pin-1 to cytoplasm. Pin-1 subsequently interacts with Serine 147 residue in TIS21 protein, resulting in mitochondrial depolarization. (2) TIS21 regulates transition of cell cycle at G1/S and G2/M phases in cancer cells with inactive pRB and/or p53, as well as in normal cells by regulating pRB/p16INK4a pathway. The latter has already been well elucidated; TIS21 inhibits the expression of cyclin D1, thus resulting in the arrest of cells at G1/S phase by pRB and p53 dependent manner. On the other hand, TIS21 inhibits degradations of cyclin A and cyclin B1 at G2/M phase, and directly binds to Cdc2, resulting in the failure of mitotic exit and then increasing the tumor cell death, when stimulated by high concentration of EGF. Therefore, TIS21 can be suggested as a pan-cell cycle modulator. (3) TIS21 regulates embryo development by activating BMP signal through interaction with Smad 1 and Smad 8, thereby regulating vertebral patterning in mice. It is also involved in notochord development in Xenopus and paraxial mesoderm development in zebrafish. Based on the previous report that the expression of TIS21 is involved in the induction of senescence after chemotherapy of cancer cells, which can be a mechanism to resist carcinogenesis, TIS21 /BTG2/ PC3 , the endogenous cell death mol...

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Section: Potential Roles Of Tis21 /Btg2/pc3mentioning

confidence: 99%

TIS21 /BTG2/PC3 as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule

Lim

2006

J Cancer Res Clin Oncol

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“…PC3 mRNA is expressed in the neuroblast of the ventricular zone of the neural tube during the last proliferative cycle before differentiation into a postmitotic neuron and is therefore a marker for the birth of the neuron (Bradbury et al, 1991;Iacopetti et al, 1994Iacopetti et al, , 1999. Moreover, the ability of PC3 to induce cell cycle arrest in G 1 by inhibiting the transcription of cyclin D1, as was observed in fibroblasts (Guardavaccaro et al, 2000), and to potentiate the NGFmediated neuronal differentiation of pheochromocytoma cells (Corrente et al, 2002;el-Ghissassi et al, 2002) suggested that PC3 could act as a switch from proliferative to neuron-generating cell fate. To test this hypothesis, we produced two transgenic mouse models conditionally overexpressing PC3 in neuroepithelia.…”

Section: Introductionmentioning

confidence: 99%

“…Rather, PC3 strongly enhanced the NGFinduced differentiation of these cells (Corrente et al, 2002;el-Ghissassi et al, 2002;F. Tirone, unpublished data).…”

Section: Pc3-dependent Induction Of Math1 and Cell Cycle Arrest Are Cmentioning

confidence: 99%

Dual Control of Neurogenesis byPC3through Cell Cycle Inhibition and Induction ofMath1

Canzoniere¹,

Farioli-Vecchioli

Conti³

et al. 2004

J. Neurosci.

101

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Growing evidence indicates that cell cycle arrest and neurogenesis are highly coordinated and interactive processes, governed by cell cycle genes and neural transcription factors. The gene PC3 (Tis21/BTG2) is expressed in the neuroblast throughout the neural tube and inhibits cell cycle progression at the G 1 checkpoint by repressing cyclin D1 transcription. We generated inducible mouse models in which the expression of PC3 was upregulated in neuronal precursors of the neural tube and of the cerebellum. These mice exhibited a marked increase in the production of postmitotic neurons and impairment of cerebellar development. Cerebellar granule precursors of PC3 transgenic mice displayed inhibition of cyclin D1 expression and a strong increase in the expression of Math1, a transcription factor required for their differentiation. Furthermore, PC3, encoded by a recombinant adenovirus, also induced Math1 in postmitotic granule cells in vitro and stimulated the Math1 promoter activity. In contrast, PC3 expression was unaffected in the cerebellar primordium of Math1 null mice, suggesting that PC3 acts upstream to Math1. As a whole, our data suggest that cell cycle exit of cerebellar granule cell precursors and the onset of cerebellar neurogenesis are coordinated by PC3 through transcriptional control of cyclin D1 and Math1, respectively.

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“…Arginine Methylation and Cancer?-A number of studies have provided evidence linking arginine methylation with antiproliferative signaling or with a protective role against cancer (13,17,(65)(66)(67)(68)(69)(70)(71)(72). However, these observations may not be applicable to all PRMTs and all cancer types.…”

Section: Complex Genomic Structure At the 5ј-end Of The Prmt1 Gene Lementioning

confidence: 99%

Alternative Splicing Yields Protein Arginine Methyltransferase 1 Isoforms with Distinct Activity, Substrate Specificity, and Subcellular Localization

Goulet

Gauvin

Boisvenue

et al. 2007

Journal of Biological Chemistry

165

200

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PRMT1 is the predominant member of a family of protein arginine methyltransferases (PRMTs) that have been implicated in various cellular processes, including transcription, RNA processing, and signal transduction. It was previously reported that the human PRMT1 pre-mRNA was alternatively spliced to yield three isoforms with distinct N-terminal sequences. Close inspection of the genomic organization in the 5-end of the PRMT1 gene revealed that it can produce up to seven protein isoforms, all varying in their N-terminal domain. A detailed biochemical characterization of these variants revealed that unique N-terminal sequences can influence catalytic activity as well as substrate specificity. In addition, our results uncovered the presence of a functional nuclear export sequence in PRMT1v2. Finally, we find that the relative balance of PRMT1 isoforms is altered in breast cancer.

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BTG2TIS21/PC3 induces neuronal differentiation and prevents apoptosis of terminally differentiated PC12 cells

Cited by 68 publications

References 29 publications

TIS21 /BTG2/PC3 as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule

TIS21 /BTG2/PC3 as a link between ageing and cancer: cell cycle regulator and endogenous cell death molecule

Dual Control of Neurogenesis byPC3through Cell Cycle Inhibition and Induction ofMath1

Alternative Splicing Yields Protein Arginine Methyltransferase 1 Isoforms with Distinct Activity, Substrate Specificity, and Subcellular Localization

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