BTK-independent regulation of calcium signalling downstream of the B-cell receptor in malignant B-cells

Aims: There is an urgent need for appropriate biomarkers that can precisely and reliably predict immunotherapy efficacy, as immunotherapy responses can differ in skin cutaneous melanoma (SKCM) patients. Methods: In this study, univariate regression models and survival analysis were used to examine the link between calcium voltage-gated channel subunit alpha 1C ( CACNA1C) mutation status and immunotherapy outcome in SKCM patients receiving immunotherapy. Mutational landscape, immunogenicity, tumor microenvironment and pathway-enrichment analyses were also performed. Results: The CACNA1C mutation group had a better prognosis, higher immunogenicity, lower endothelial cell infiltration, significant enrichment of antitumor immune response pathways and significant downregulation of protumor pathways. Conclusion: CACNA1C mutation status is anticipated to be a biomarker for predicting melanoma immunotherapy effectiveness.

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CACNA1C Mutation as a Prognosis Predictor of Immune Checkpoint Inhibitor in Skin Cutaneous Melanoma

Huang

Lin

et al. 2023

Immunotherapy

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BTK-independent regulation of calcium signalling downstream of the B-cell receptor in malignant B-cells

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References 69 publications

CACNA1C Mutation as a Prognosis Predictor of Immune Checkpoint Inhibitor in Skin Cutaneous Melanoma

CACNA1C Mutation as a Prognosis Predictor of Immune Checkpoint Inhibitor in Skin Cutaneous Melanoma

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