Btk29A Promotes Wnt4 Signaling in the Niche to Terminate Germ Cell Proliferation in
            <i>Drosophila</i>

Hamada-Kawaguchi, Noriko; Nore, Beston F.; Kuwada, Yusuke; Smith, C. I. Edvard; Yamamoto, Daisuke

doi:10.1126/science.1244512

Cited by 48 publications

(64 citation statements)

References 25 publications

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“…Several constituents of ECs are known to be involved in silencing BMP ligands and facilitators. These include molecules necessary for regulating the cellular processes that contact germline cells (as exemplified by Rho; Kirilly et al, 2011), EGFR (Liu et al, 2010), Wnt pathway components (Hamada-Kawaguchi et al, 2014;Luo et al, 2015;Wang et al, 2015;Mottier-Pavie et al, 2016), Piwi (Ma et al, 2014) and multiple regulators of chromatin modifications (Eliazer et al, 2011;Wang et al, 2011;Xuan et al, 2013;Maimon et al, 2014). Here, we report that the Hh and Hpo/Yki pathways also serve to suppress BMP ligand production in ECs.…”

Section: Discussionmentioning

confidence: 79%

Yorkie and Hedgehog independently restrict BMP production in escort cells to permit germline differentiation in the Drosophila ovary

2017

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Multiple signaling pathways guide the behavior and differentiation of both germline stem cells (GSCs) and somatic follicle stem cells (FSCs) in the Drosophila germarium, necessitating careful control of signal generation, range and responses. Signal integration involves escort cells (ECs), which promote differentiation of the GSC derivatives they envelop, provide niche signals for FSCs and derive directly from FSCs in adults. Hedgehog (Hh) signaling induces the Hippo pathway effector Yorkie (Yki) to promote proliferation and maintenance of FSCs, but Hh also signals to ECs, which are quiescent. Here, we show that in ECs both Hh and Yki limit production of BMP ligands to allow germline differentiation. Loss of Yki produced a more severe germarial phenotype than loss of Hh signaling and principally induced a different BMP ligand. Moreover, Yki activity reporters and epistasis tests showed that Yki does not mediate the key actions of Hh signaling in ECs. Thus, both the coupling and output of the Hh and Yki signaling pathways differ between FSCs and ECs despite their proximity and the fact that FSCs give rise directly to ECs.

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Section: Discussionmentioning

confidence: 79%

Yorkie and Hedgehog independently restrict BMP production in escort cells to permit germline differentiation in the Drosophila ovary

2017

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“…It has been well documented that the BMP/Dpp signaling derived from niche CpCs locally suppresses GSC differentiation by silencing bam transcription in GSCs [7,10]. Recent studies identified several factors as niche regulators in ECs that control GSC/CB differentiation [42][43][44]. However, fate determination between stem cell self-renewal and differentiation must be under strict control to ensure proper development and tissue homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Ci antagonizes Hippo signaling in the somatic cells of the ovary to drive germline stem cell differentiation

Kan

Chen

et al. 2015

Cell Res

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“…Wnt9a is more closely related to Drosophila DWnt4 than to other members of the WNT family in mammals (Bergstein et al 1997). DWnt4 is expressed in the somatic escort cells and promotes the passage from proliferation to germ cell differentiation via expression of RNA-binding protein Piwi by DCtnnb1 in Drosophila (Hamada-Kawaguchi et al 2014). The Piwi-interacting RNA pathway plays important roles in silencing of repeat elements through repressive histone modifications (Sienski et al 2012).…”

Section: Rspo1mentioning

confidence: 98%

The Battle of the Sexes: Human Sex Development and Its Disorders

Biason‐Lauber

2016

Results and Problems in Cell Differentiation

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The process of sexual differentiation is central for reproduction of almost all metazoan and therefore for maintenance of practically all multicellular organisms. In sex development we can distinguish two different processes: First, sex determination is the developmental decision that directs the undifferentiated embryo into a sexually dimorphic individual. In mammals, sex determination equals gonadal development. The second process known as sex differentiation takes place once the sex determination decision has been made through factors produced by the gonads that determine the development of the phenotypic sex. Most of the knowledge on the factors involved in sexual development came from animal models and from studies of cases in whom the genetic or the gonadal sex does not match the phenotypical sex, i.e., patients affected by disorders of sex development (DSD). Generally speaking, factors influencing sex determination are transcriptional regulators, whereas factors important for sex differentiation are secreted hormones and their receptors. This review focuses on the factors involved in gonadal determination, and whenever possible, references on the "prismatic" clinical cases are given.

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Btk29A Promotes Wnt4 Signaling in the Niche to Terminate Germ Cell Proliferation in Drosophila

Cited by 48 publications

References 25 publications

Yorkie and Hedgehog independently restrict BMP production in escort cells to permit germline differentiation in the Drosophila ovary

Yorkie and Hedgehog independently restrict BMP production in escort cells to permit germline differentiation in the Drosophila ovary

Ci antagonizes Hippo signaling in the somatic cells of the ovary to drive germline stem cell differentiation

The Battle of the Sexes: Human Sex Development and Its Disorders

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