2024
DOI: 10.3390/cancers16193291
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BUB1 Inhibition Overcomes Radio- and Chemoradiation Resistance in Lung Cancer

Shivani Thoidingjam,
Sushmitha Sriramulu,
Oudai Hassan
et al.

Abstract: Background: Despite advances in targeted therapies and immunotherapies, traditional treatments like microtubule stabilizers (paclitaxel, docetaxel), DNA-intercalating platinum drugs (cisplatin), and radiation therapy remain essential for managing locally advanced and metastatic lung cancer. Identifying novel molecular targets could enhance the efficacy of these treatments. Hypothesis: We hypothesize that BUB1 (Ser/Thr kinase) is overexpressed in lung cancers and its inhibition will sensitize lung cancers to ch… Show more

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