Bubble-based acoustic radiation force elasticity imaging

Erpelding, Todd N.; Hollman, Kyle W.; O’Donnell, Matthew

doi:10.1109/tuffc.2005.1504019

Cited by 57 publications

(51 citation statements)

References 23 publications

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“…An ultrafast Nd:glass laser (IntraLase Corp., Irvine, CA), described previously (Erpelding et al, 2005a), used 800 fs, 1053 nm pulses to create target microbubbles by LIOB. A mechanical shutter controlled the number of laser pulses delivered (3,000-25,000), while a neutral density filter controlled the laser pulse energy.…”

Section: Laser-induced Optical Breakdown (Liob)mentioning

confidence: 99%

“…Nonlinear radial oscillations of the bubble were avoided by using an insonation frequency much greater than the bubble resonance frequency. Bubble size was monitored during radiation force measurements using the magnitude of acoustic backscatter (Erpelding et al, 2005a(Erpelding et al, , 2006, as described below.…”

Section: Laser-induced Optical Breakdown (Liob)mentioning

confidence: 99%

“…Acoustic radiation force is a potentially promising in vivo tool since local lens deformation can be generated non-invasively and warrants further investigation. Previous research demonstrated that bubble displacements from acoustic radiation force are inversely related to the material Young's modulus (Erpelding et al, 2005a). Temporal characteristics of the bubble displacement and subsequent recovery are indicative of local viscoelastic properties.…”

Section: Introductionmentioning

confidence: 98%

“…Recently, bubble-based acoustic radiation force was introduced to measure tissue elastic properties with high spatial resolution (Erpelding et al, 2004(Erpelding et al, , 2005a(Erpelding et al, , 2005b. In this technique, acoustic radiation force is applied to a microbubble created by laser-induced optical breakdown (LIOB).…”

Section: Introductionmentioning

confidence: 99%

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Mapping age-related elasticity changes in porcine lenses using bubble-based acoustic radiation force

Erpelding

Hollman

O’Donnell

2007

Experimental Eye Research

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Bubble-based acoustic radiation force aims to measure highly localized tissue viscoelastic properties. In the current investigation, acoustic radiation force was applied to laser-induced bubbles to measure age-related changes in the spatial distribution of elastic properties within in vitro porcine lenses. A potential in vivo technique to map lens elasticity is crucial to understanding the onset of presbyopia and develop new treatment options. Bubble-based acoustic radiation force was investigated as a technique to measure the spatial elasticity distribution of the lens in its natural state without disrupting the lens capsule.Laser-induced optical breakdown (LIOB) generated microbubbles in a straight line across the equatorial plane of explanted porcine lenses with 1 mm lateral spacing. Optical breakdown occurs when sufficiently high threshold fluence is attained at the focus of femtosecond pulsed lasers, inducing plasma formation and bubble generation. A two-element confocal ultrasonic transducer applied 6.5 ms acoustic radiation force-chirp bursts with the 1.5 MHz outer element while monitoring bubble position within the lens using pulse-echoes with the 7.44 MHz inner element. A crosscorrelation method was used to measure bubble displacements and determine exponential time constants of the temporal responses. Maximum bubble displacements are inversely proportional to the local Young's modulus, while time constants are indicative of viscoelastic properties.The apparent spatial elasticity distributions in 41 porcine lenses, ranging from 4 months to 5 years in age, were measured using bubble-based acoustic radiation force. Bubble displacements decrease closer to the porcine lens center, suggesting that the nucleus is stiffer than the cortex. Bubble displacements decrease with increasing lens age, suggesting that porcine lenses become stiffer with age. Bubble-based acoustic radiation force may be well-suited as a potential in vivo technique to spatially map elastic properties of the lens and guide therapeutic procedures aimed at restoring accommodation.

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Section: Laser-induced Optical Breakdown (Liob)mentioning

confidence: 99%

Section: Laser-induced Optical Breakdown (Liob)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mapping age-related elasticity changes in porcine lenses using bubble-based acoustic radiation force

Erpelding

Hollman

O’Donnell

2007

Experimental Eye Research

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“…This may be due to the difficulty of constructing a physically realistic phantom and the low interaction between the image processing and phantom design communities. Almost all of the reported cardiac-like ultrasound phantoms, are designed for tissue characterization or strain measurements [11][12][13] rather than for assessing segmentation of the boundary of the myocardium.…”

Section: Evaluating and Explaining Accuracymentioning

confidence: 99%

Evaluation of a Cardiac Ultrasound Segmentation Algorithm Using a Phantom

Yue

Tagare

Madsen

et al. 2008

Medical Image Computing and Computer-Assisted Intervention – MICCAI 2008

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This paper evaluates the performance of a level set algorithm for segmenting the endocardium in short-axis ultrasound images. The evaluation is carried out using an anthropomorphic ultrasound phantom. Details of the phantom design, including comparison of the ultrasound parameters with invitro measurements, are included.In addition to measuring segmentation accuracy, the effectiveness of the energy minimization scheme is also determined. It is argued that using the phantom along with global minimization algorithms (simulated annealing and random search) makes is possible to assess the minimization strategy.

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Monitoring/Imaging and Regenerative Agents for Enhancing Tissue Engineering Characterization and Therapies

et al. 2015

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The past three decades have seen numerous advances in tissue engineering and regenerative medicine (TERM) therapies. However, despite the successes there is still much to be done before TERM therapies become commonplace in clinic. One of the main obstacles is the lack of knowledge regarding complex tissue engineering processes. Imaging strategies, in conjunction with exogenous contrast agents, can aid in this endeavor by assessing in vivo therapeutic progress. The ability to uncover real-time treatment progress will help shed light on the complex tissue engineering processes and lead to development of improved, adaptive treatments. More importantly, the utilized exogenous contrast agents can double as therapeutic agents. Proper use of these Monitoring/Imaging and Regenerative Agents (MIRAs) can help increase TERM therapy successes and allow for clinical translation. While other fields have exploited similar particles for combining diagnostics and therapy, MIRA research is still in its beginning stages with much of the current research being focused on imaging or therapeutic applications, separately. Advancing MIRA research will have numerous impacts on achieving clinical translations of TERM therapies. Therefore, it is our goal to highlight current MIRA progress and suggest future research that can lead to effective TERM treatments.

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Bubble-based acoustic radiation force elasticity imaging

Cited by 57 publications

References 23 publications

Mapping age-related elasticity changes in porcine lenses using bubble-based acoustic radiation force

Mapping age-related elasticity changes in porcine lenses using bubble-based acoustic radiation force

Evaluation of a Cardiac Ultrasound Segmentation Algorithm Using a Phantom

Monitoring/Imaging and Regenerative Agents for Enhancing Tissue Engineering Characterization and Therapies

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