Bubbles in microfluidics: an all-purpose tool for micromanipulation

Li, Yuyang; Liu, Xiaoming; Huang, Qiang; Ohta, Aaron T.; Arai, Tatsuo

doi:10.1039/d0lc01173h

Cited by 52 publications

(27 citation statements)

References 203 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 121 Moreover, bubble-based robotics and on-a-chip systems should help to develop novel acoustic micro/nanomotors and sensors. 122 For the purpose of this Perspective, we are concerned with acoustoflow synthesis at the meso- and microscale levels. Unlike batch conditions, flow and microflow devices exhibit enhanced heat and mass transfers along with improved reaction kinetics, due to the small path occupied by reagents in channels of microscopic diameters, and enable the preparation of organic compounds, especially active pharmaceutical ingredients.…”

Section: Flow and Automation: The Present And Futurementioning

confidence: 99%

“…While industrial applications of acoustic and hydrodynamic cavitation require scale-up considerations (reactor design for instance), , which are not covered here, ultrasound and flow systems are ideal partners as one moves downward, i.e., miniaturization , because acoustic microfluidics constitutes an emerging technology enabling cell and particle manipulation . Moreover, bubble-based robotics and on-a-chip systems should help to develop novel acoustic micro/nanomotors and sensors . For the purpose of this Perspective, we are concerned with acoustoflow synthesis at the meso- and microscale levels.…”

Section: Flow and Automation: The Present And Futurementioning

confidence: 99%

See 1 more Smart Citation

Organic Sonochemistry: A Chemist’s Timely Perspective on Mechanisms and Reactivity

2021

View full text Add to dashboard Cite

Sonochemistry, the use of sound waves, usually within the ultrasonic range (>20 kHz), to boost or alter chemical properties and reactivity constitutes a long-standing and sustainable technique that has, however, received less attention than other activation protocols despite affordable setups. Even if unnecessary to underline the impact of ultrasound-based strategies in a broad range of chemical and biological applications, there is considerable misunderstanding and pitfalls regarding the interpretation of cavitational effects and the actual role played by the acoustic field. In this Perspective, with an eye on mechanisms in particular, we discuss the potentiality of sonochemistry in synthetic organic chemistry through selected examples of past and recent developments. Such examples illustrate specific controlling effects and working rules. Looking back at the past while looking forward to advancing the field, some essentials of sonochemical activation will be distilled.

show abstract

Section: Flow and Automation: The Present And Futurementioning

confidence: 99%

Section: Flow and Automation: The Present And Futurementioning

confidence: 99%

Organic Sonochemistry: A Chemist’s Timely Perspective on Mechanisms and Reactivity

2021

View full text Add to dashboard Cite

show abstract

“…Microbubbles are generally defined as bubbles with an outer diameter of less than one millimeter but larger than one micrometer [ 1 ]. Microbubbles have important applications in many fields [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…The external force applied at the gas–liquid interface can be used to manipulate the microparticles and the microbubbles in a non-contact manner. This non-contact manipulation property allows for unique and effective applications of microbubbles in microfluidics, which have a wide range of applications [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Growth of Laser-Induced Microbubbles inside Capillary Tubes Affected by Gathered Light-Absorbing Particles

Wang

et al. 2022

Micromachines

View full text Add to dashboard Cite

Microbubbles have important applications in optofluidics. The generation and growth of microbubbles is a complicated process in microfluidic channels. In this paper, we use a laser to irradiate light-absorbing particles to generate microbubbles in capillary tubes and investigate the factors affecting microbubble size. The results show that the key factor is the total area of the light-absorbing particles gathered at the microbubble bottom. The larger the area of the particles at bottom, the larger the size of the microbubbles. Furthermore, the area is related to capillary tube diameter. The larger the diameter of the capillary tube, the more particles gathered at the bottom of the microbubbles. Numerical simulations show that the Marangoni convection is stronger in a capillary tube with a larger diameter, which can gather more particles than that in a capillary tube with a smaller diameter. The calculations show that the particles in contact with the microbubbles will be in a stable position due to the surface tension force.

show abstract

“…In biomedical microfluidic experiments, the bubbles existing in the tube will seriously reduce the measurement accuracy. However, whether bubbles are generated depends on many factors, such as the pumping actuation, pressure differences along their path, different pressures between the inside and outside of the liquid surface, etc., so they are difficult to avoid and eliminate [4,5].…”

Section: Introductionmentioning

confidence: 99%

A Fast Bubble Detection Method in Microtubes Based on Pulsed Ultrasound

et al. 2021

Micromachines

View full text Add to dashboard Cite

In the process of biological microfluidic manipulation, the bubbles generated in the tube will seriously reduce the gauging accuracy. This paper introduces an improving method that can estimate the size of microbubbles in real time. Hence, the measurement data of the liquid volume can be modified according to this method. A microbubble detector based on the pulsed-ultrasound method was studied, including the device structure and the working principle. The assessment formula of the microbubbles in the tube was derived from the simulation results, which adopted the two-phase theory. The digital image processing method was applied to fulfill the microbubble calibration. This detection method was applied to measure the microbubbles in the tube and to modify the flow volume in a timely manner. The results of the experiments showed that this method is effective at improving the microflow gauging accuracy.

show abstract

Bubbles in microfluidics: an all-purpose tool for micromanipulation

Abstract: In the last decade, the integration of microfluidic devices and multiple actuation technologies at the microscale has greatly contributed to the progress of related fields. In particular, microbubbles are playing...

Cited by 52 publications

References 203 publications

Organic Sonochemistry: A Chemist’s Timely Perspective on Mechanisms and Reactivity

Organic Sonochemistry: A Chemist’s Timely Perspective on Mechanisms and Reactivity

Growth of Laser-Induced Microbubbles inside Capillary Tubes Affected by Gathered Light-Absorbing Particles

A Fast Bubble Detection Method in Microtubes Based on Pulsed Ultrasound

Contact Info

Product

Resources

About