Buccal Absorption of Drugs

Beckett, A. H.; Hossie, R. D.

doi:10.1007/978-3-642-65052-9_3

Cited by 32 publications

(22 citation statements)

References 24 publications

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“…Much of the literature dealing with oral mucosal permeability has been concerned with drug absorption and the relationship between the structure of a compound and its ability to penetrate the tissue, and there have been a number of studies on the kinetics of drug absorption across oral mucosa (see Beckett and Hossie, 11 Moffat, 12 Siegel et al, 13 and Siegel 14 for reviews). The earliest studies on the oral absorption of drugs compared systemic effects after oral and cutaneous delivery.…”

Section: A In Vivo Methodsmentioning

confidence: 99%

Permeability of Oral Mucosa

Squier¹,

Johnson²

1975

British Medical Bulletin

113

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ABSTRACT:In discussing permeability, we are describing one of the fundamental barrier functions of oral mucosa. Despite assumptions to the contrary, the oral mucosa is not a uniformly, highly permeable tissue like gut, but shows regional variation. The keratinized areas, such as gingiva and hard palate, are least permeable and nonkeratinized lining areas are most permeable. This variation appears to reflect differences in the types of lipid making up the intercellular permeability barrier in the superficial layers of the epithelium. Differences in permeability may be related to regional differences in the prevalence of certain mucosal diseases and can be utilized to advantage for local and systemic drug delivery.

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Section: A In Vivo Methodsmentioning

confidence: 99%

Permeability of Oral Mucosa

Squier¹,

Johnson²

1975

British Medical Bulletin

113

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“…In man the stratified squamous epithelium of thp mouth does not undergo complete keratinization (28). The absorption of some compounds via the buccal route is greater than by the oral route (29 …”

Section: Sumarymentioning

confidence: 99%

In Vitro and In Vivo Measurement of Percutaneous Penetration of Low Molecular Weight Toxins of Military Interest

Kemppainen¹,

Mehta²,

Stafford³

et al. 1989

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“…Apparent partition coefficients were measured using the n-heptane-water system; this has previously been used to relate the lipid-solubility of certain organic acids and bases with their buccal absorption in man (Beckett & Moffat, 1969;Beckett & Hossie, 1971).…”

Section: Apparent Partition Coeficientsmentioning

confidence: 99%

Trialkylsilyl moieties as potential pharmacokinetic modifying groups for aminoalcohols

Beckett¹,

Taylor²,

Gorrod³

1975

Journal of Pharmacy and Pharmacology

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Water soluble derivatives of the aminoalcohols methylephedrine, ephedrine and norephedrine have been synthesized to contain various trialkyl silyl groups attached to the hydroxyl group of the aminoalcohol hydrochloride. Variation of the alkyl substituents on the silyl group produces a wide variety of derivatives possessing differing lipid solubilities and rates of hydrolysis to the parent aminoalcohol.

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Buccal Absorption of Drugs

Cited by 32 publications

References 24 publications

Permeability of Oral Mucosa

Permeability of Oral Mucosa

In Vitro and In Vivo Measurement of Percutaneous Penetration of Low Molecular Weight Toxins of Military Interest

Trialkylsilyl moieties as potential pharmacokinetic modifying groups for aminoalcohols

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