Buccal delivery of small molecules and biologics: Of mucoadhesive polymers, films, and nanoparticles – An update

Nair, Varsha V; Cabrera-Barona, Pablo; Ramírez-Lecaros, Constanza; Jara, Miguel; Brayden, David J.; Morales, Javier

doi:10.1016/j.ijpharm.2023.122789

Cited by 25 publications

(4 citation statements)

References 149 publications

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“…Entretanto, poucos estudos têm sido realizados para demonstrar as possíveis interações que possam existir entre nanossistemas e os tecidos da mucosa oral, principalmente na ausência de estabilizadores que podem influenciar a característica da formulação de entrega de fármacos na mucosa oral, onde o fluxo de saliva representa grande desafio para uma administração eficaz (Nair et al, 2023). Qualquer mudança no volume e no fluxo da saliva pode acarretar diluição, alterações de pH e degradação enzimática causando uma exposição residual não uniforme do fármaco (Esposito et al, 2020).…”

Section: Principais Formulações Nanoestruturadas Utilizadas Na Mucosa...unclassified

Dermatofibrossarcoma Protuberans: Uma Revisão Abrangente Da Epidemiologia, Diagnóstico, Tratamento E Prognóstico

Cunha,

Silva,

Oliveira

et al. 2023

A Pesquisa Em Saúde: Desafios Atuais E Perspectivas Futuras 5

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Section: Principais Formulações Nanoestruturadas Utilizadas Na Mucosa...unclassified

Dermatofibrossarcoma Protuberans: Uma Revisão Abrangente Da Epidemiologia, Diagnóstico, Tratamento E Prognóstico

Cunha,

Silva,

Oliveira

et al. 2023

A Pesquisa Em Saúde: Desafios Atuais E Perspectivas Futuras 5

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“…provide a high rate of drug absorption into the systemic circulation, reduce first-pass metabolism compared to oral dosage forms, and protect drugs from entering the aggressive environment of the gastrointestinal tract [6][7][8]. Topical oral drug delivery systems (primarily oromucosal patches) can also provide prolonged drug residence time at the desired site as well as unidirectional drug release [9][10][11]. For this protect drugs from entering the aggressive environment of the gastrointestinal tract [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…For this protect drugs from entering the aggressive environment of the gastrointestinal tract [6][7][8]. Topical oral drug delivery systems (primarily oromucosal patches) can also provide prolonged drug residence time at the desired site as well as unidirectional drug release [9][10][11]. For this purpose, polymeric drug delivery systems must have high mucoadhesion to maintain prolonged contact with the mucosa under wet oral cavity conditions, as well as provide programmed and controlled drug release and high drug absorption levels [12].…”

Section: Introductionmentioning

confidence: 99%

Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D

Dubashynskaya,

Petrova,

Skorik

2024

IJMS

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Oromucosal drug delivery, both local and transmucosal (buccal), is an effective alternative to traditional oral and parenteral dosage forms because it increases drug bioavailability and reduces systemic drug toxicity. The oral mucosa has a good blood supply, which ensures that drug molecules enter the systemic circulation directly, avoiding drug metabolism during the first passage through the liver. At the same time, the mucosa has a number of barriers, including mucus, epithelium, enzymes, and immunocompetent cells, that are designed to prevent the entry of foreign substances into the body, which also complicates the absorption of drugs. The development of oromucosal drug delivery systems based on mucoadhesive biopolymers and their derivatives (especially thiolated and catecholated derivatives) is a promising strategy for the pharmaceutical development of safe and effective dosage forms. Solid, semi-solid and liquid pharmaceutical formulations based on biopolymers have several advantageous properties, such as prolonged residence time on the mucosa due to high mucoadhesion, unidirectional and modified drug release capabilities, and enhanced drug permeability. Biopolymers are non-toxic, biocompatible, biodegradable and may possess intrinsic bioactivity. A rational approach to the design of oromucosal delivery systems requires an understanding of both the anatomy/physiology of the oral mucosa and the physicochemical and biopharmaceutical properties of the drug molecule/biopolymer, as presented in this review. This review summarizes the advances in the pharmaceutical development of mucoadhesive oromucosal dosage forms (e.g., patches, buccal tablets, and hydrogel systems), including nanotechnology-based biopolymer nanoparticle delivery systems (e.g., solid lipid particles, liposomes, biopolymer polyelectrolyte particles, hybrid nanoparticles, etc.).

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“…Processes 2023, 11, 2628 2 of 19 Oral films can be orodispersible films (fast-dissolving oral films or oral dissolving films-ODF) [33][34][35][36][37][38][39][40][41][42][43][44][45] and mucoadhesive buccal films (MBF) [46][47][48][49][50][51][52][53]. The ODFs are formulated for rapid drug release and subsequent absorption in the oral cavity or digestive tract [54][55][56].…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview

Ozon,

Sarbu,

Popovici

et al. 2023

Processes

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The interest in buccal drug delivery is under consideration due to some distinct properties compared to the traditional pharmaceutical formulations for oral administration: significantly higher bioavailability, a faster absorption rate of the drug, and substantial compliance for special needs patients. Oral films are obtained through various technologies, from conventional tools to 3D and 4D printing approaches. This minireview aims to describe the current additive manufacturing technologies in oral film fabrication, display their advantages and limitations, and discuss various formulation strategies. It also provides advanced data regarding synthetic and natural polymers used in 3D printing technologies for oral films. Moreover, it shows the most recent studies with 3D-printed orodispersible films and mucoadhesive buccal films manufactured through previously analyzed methods. Finally, conclusions and future perspectives are also briefly summarized.

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Buccal delivery of small molecules and biologics: Of mucoadhesive polymers, films, and nanoparticles – An update

Cited by 25 publications

References 149 publications

Dermatofibrossarcoma Protuberans: Uma Revisão Abrangente Da Epidemiologia, Diagnóstico, Tratamento E Prognóstico

Dermatofibrossarcoma Protuberans: Uma Revisão Abrangente Da Epidemiologia, Diagnóstico, Tratamento E Prognóstico

Biopolymer Drug Delivery Systems for Oromucosal Application: Recent Trends in Pharmaceutical R&D

Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview

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