This paper addresses the flexural–torsional stability of functionally graded (FG) nonlocal thin-walled beam-columns with a tapered I-section. The material composition is assumed to vary continuously in the longitudinal direction based on a power-law distribution. Possible small-scale effects are included within the formulation according to the Eringen nonlocal elasticity assumptions. The stability equations of the problem and the associated boundary conditions are derived based on the Vlasov thin-walled beam theory and energy method, accounting for the coupled interaction between axial and bending forces. The coupled equilibrium equations are solved numerically by means of the differential quadrature method (DQM) to determine the flexural–torsional buckling loads associated to the selected structural system. A parametric study is performed to check for the influence of some meaningful input parameters, such as the power-law index, the nonlocal parameter, the axial load eccentricity, the mode number and the tapering ratio, on the flexural–torsional buckling load of tapered thin-walled FG nanobeam-columns, whose results could be used as valid benchmarks for further computational validations of similar nanosystems.