The initial delamination defects may arise during the preparation of carbon fiber-reinforced polymer (CFRP) composite laminates, so its effects need to be considered in the evolution of mechanical properties. In this article, the behaviors of composite laminates with initial delamination defects under impact and compression after impact (CAI) are investigated by numerical method. The simulation framework composed of the micromechanics of failure (MMF) theory and the mixed mode exponential cohesive zone model (ECZM) is constructed. The numerical analysis compares the effects of the interaction between four different initial delamination defects and impact loading on impact response and CAI strength at two impact velocity levels (1.336 and 2.314 m/s). Furthermore, the failure mechanisms of laminates with initial delamination defect are disclosed under CAI loading. The findings indicate