Metallic strip flexible pipes (MSFP), a relatively new style of unbonded flexible pipes, are considered as an attractive alternative to traditional submarine pipes. During its reeling operation, it will inevitably confront various complicated loads, which may affect the integrity and safety of MSFP's utilization. In this paper, the tension-extension and moment-curvature relation of MSFP were obtained by laboratorial tests. The mechanical properties were then imported into the global model established in ABAQUS. The finite element model was adopted to predict the deformation and mechanical responses of MSFP during the operation process. Besides, the effects of reeling length, the diameter of the coiling drum, and the pulling force were discussed. The obtained conclusions will provide some references for optimizing MSFP design and preventing possible damage in the reeling operation.