Budd-Chiari syndrome: a rare and life-threatening complication of Crohn’s disease

Simões, Camila; Ghouri, Yezaz A.; Merwat, Shehzad; Stevenson, Heather L.

doi:10.1136/bcr-2017-222946

Cited by 4 publications

(1 citation statement)

References 27 publications

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“…BCS has rarely been associated with in ammatory bowel disease (19,20,21,22) . However, 5 of our 21 BCS patients (24%) had Crohn's disease where 3 of them were on TNF alpha antagonist treatment.…”

Section: Discussionmentioning

confidence: 99%

The Potential Role of Transient Elastography in Assessing Patients with Primary Budd Chiari Syndrome

Webb¹,

Shibolet²,

Lurie³

et al. 2020

JJGH

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Background: Budd-Chiari syndrome (BCS) is a rare disease de ned as hepatic venous out ow obstruction at any level from the hepatic venules up to the cavo-atrial junction. Transjugular Intrahepatic Portosystemic Shunt (TIPS) is performed as a decompressive treatment in some patients.Aim: To evaluate the potential role of Transient Elastography (TE) in assessing liver stiffness in patients with primary BCS. Methods: Twenty one BCS patients and 10 patients with liver cirrhosis with different underlying etiologies underwent abdominal ultrasound and TE.Results: Ninety-ve percent of BCS patients had liver stiffness compatible with F4 with a median of 21 kPa, values which are usually obtained in patients with liver cirrhosis. Ten BCS and 10 cirrhotic patients underwent repeated TE with a median of 320 days between exams for BCS and 4.5 years for cirrhotic patients. The change of liver stiffness in BCS patients was 5.75 kPa (range − 0.4 to 26.6), compared with − 4.85 kPa (range − 15.6 to 15.0) in cirrhotic patients (p-value = 0.0029). Change in liver stiffness from baseline to follow-up in BCS patients who underwent TIPS (n = 4) was 0.2 kPa (range − 0.4 to 15.3), whereas in patients without intervention (n = 6) it was 6.75 kPa (range 1.3 to 26.6). The difference was not statistically signi cant.Conclusion: Liver stiffness in BCS patients is a dynamic progressive process with parameters of TE resembling liver cirrhosis. Even if TIPS seem to slow down the increment of liver stiffness, because of decreased liver congestion, it kept most patients with high score. The TE in BCS patients may be considered for monitoring for stable or upfront disease deterioration.

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Section: Discussionmentioning

confidence: 99%

The Potential Role of Transient Elastography in Assessing Patients with Primary Budd Chiari Syndrome

Webb¹,

Shibolet²,

Lurie³

et al. 2020

JJGH

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Affective temperament in inflammatory bowel diseases: Another brick in the wall of differentiation

et al. 2018

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Psychiatric disorders are significantly common complications among patients suffering from inflammatory bowel diseases (IBD). Affective temperament is a concept of core personality traits, which can decribe the vulnerability to mood disorders, therefore its evaluation might convey useful information about patients' mental status in autoimmune disorders. The aim of the study was to evaluate the affective temperament in patients with Crohn's disease (CD) and ulcerative colitis (UC) as characteristic features of these diseases, but also in the clinical course and the severity of anxiety and depression.Due to our knowledge this is the first study of this kind. The study enrolled 130 patients with IBD, including 68 with CD and 62 with UC. We used TEMPS-A to evaluate affective temperament and HADS scales to assess the intensity of depressive and anxiety symptoms. Harvey Bradshaw scale, Crohn’s Disease Activity Index (CDAI) and Mayo Score were used to evaluate clinical severity of the diseases. We observed significantly higher prevalence of depressive, cyclothymic and anxiety temperaments in CD patients compared to the control group. Harvey Bradshaw scale, CDAI and Mayo Self Report showed statistically significant outcomes, including significant positive correlations with depressive, cyclothymic and anxiety subscales of TEMPS-A, and negative correlation with the hyperthymic temperament in CD subjects. Our findings indicate significant differences between CD and UC due to temperament traits, and suggest distinct pathogenesis of mood disorders in IBD.

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Non-cirrhotic portal hypertension in inflammatory bowel disease

Mir

Sorrentino

2023

Minerva Gastroenterol

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Budd-Chiari syndrome: a rare and life-threatening complication of Crohn’s disease

Cited by 4 publications

References 27 publications

The Potential Role of Transient Elastography in Assessing Patients with Primary Budd Chiari Syndrome

The Potential Role of Transient Elastography in Assessing Patients with Primary Budd Chiari Syndrome

Affective temperament in inflammatory bowel diseases: Another brick in the wall of differentiation

Non-cirrhotic portal hypertension in inflammatory bowel disease

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