Budding invasive margin and prognosis in colorectal cancer – no direct association with β-catenin expression

Hörkkö, Tuomo T.; Klintrup, Kai; Mäkinen, Johanna M.; Näpänkangas, Juha; Tuominen, Hannu; Mäkelä, Jyrki; Karttunen, Tuomo J.; Mäkinen, Markus J.

doi:10.1016/j.ejca.2006.01.017

Cited by 36 publications

(21 citation statements)

References 19 publications

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“…It is important to mention that our study is not entirely comparable with previous reports on CRC: firstly, the assessed proteins have not been studied in SAC; secondly, the CCs were selected to match the SAC series; and thirdly, previous studies, except that by Shinto et al [22], did not evaluate the immunohistochemical patterns in the different tumor areas as we present here. With this proviso, the 51.9% and the 25% strong positive nuclear β-catenin found by Hörkko et al in the IF and the CT, respectively, are comparable to the 61% and 18.6% reported by us in the non-TB IF and the CT [23]. The percentage of negative Ecadherin found in our CC cases at the non-TB IF and in the CT (1.7% in both locations) is comparable to the 7% reported elsewhere in CRC [24].…”

Section: Discussionsupporting

confidence: 93%

“…We therefore considered that the canonical Wnt pathway, highlighted by β-catenin translocation into the nucleus, is not the major cause of TB formation in SACs and that other molecular pathways may be responsible for TB formation mainly in proximal and, to a lesser extent, in distal and rectal SACs. This is consistent with previous CRC research that concluded that, although nuclear β-catenin was often found at the invasive margin, it is unlikely to be the sole cause of budding [23]. Furthermore, a study carried out in precursor lesions of CCs and SACs showed that nuclear β-catenin was more frequently observed in conventional tubular adenomas than in serrated adenomas [25].…”

Section: Discussionsupporting

confidence: 88%

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Immunohistochemical expression profile of β-catenin, E-cadherin, P-cadherin, laminin-5γ2 chain, and SMAD4 in colorectal serrated adenocarcinoma

et al. 2012

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 88%

Immunohistochemical expression profile of β-catenin, E-cadherin, P-cadherin, laminin-5γ2 chain, and SMAD4 in colorectal serrated adenocarcinoma

et al. 2012

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“…Results indicate that complexity index of tumor is not associated with β-catenin and E-cadherin expression in colon carcinoma. Other researchers, in agreement with our findings, describe the similar results [21,45]. When we compare complexity index with other clinicopathological parameters of the patients, differentiation of tumor and Duke's stages were significantly associated with complexity index (p=0.002 and p=0.026 respectively).…”

Section: Discussionsupporting

confidence: 80%

Expression of β-Catenin and E-Cadherin, their Clinical Significance and Association with Complexity Index of Colon Carcinoma

Ahmad¹,

Hahn-Strömberg²

2016

Adv Genet Eng

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Cell-cell adhesion and communication relies greatly on the E-cadherin/catenin system. Deregulation in this system may result in phenotypic change, which may create an opportunity for tumor cells to differentiate, metastasize and invade neighbouring tissue. In this study, we aimed to assess the protein expression of E-cadherin and β-catenin in the patients diagnosed with colon carcinoma correlating the levels with growth pattern of tumors using complexity index analysis as well as clinical and pathological features of the patients.129 colon carcinoma patients were selected to evaluate the protein expression of E-cadherin and β-catenin through immunohistochemical staining. Complexity index of randomly selected patients diagnosed with colon carcinoma was calculated to examine the growth pattern of the tumor.Expression of adhesion proteins was significantly perturbed in colon carcinoma patients as compared with normal mucosa (p<0.05). Similarly the growth pattern of tumor i.e., complexity index value was significantly related to differentiation of the tumor (p=0.002) and Duke's stages (p=0.026).Our results suggest that E-cadherin and β-catenin may play an indicative role in colorectal cancer invasion and disease progression which may act as prognostic markers in colorectal carcinoma. Also complexity index and adhesive proteins distribution are two independent markers which should aid the development of novel strategies for prevention as well as individual treatment of colon carcinoma.

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“…Tumor buds themselves shows a strong and uniform nuclear beta-catenin staining and concomitant loss of membranous E-cadherin expression, in line with what is seen in EMT studies [21,55,56]. In addition, over-expression of ECM degradation proteins MMP-2 and MMP-9, uPAR, and laminin5γ2 have all been reported [41,57-59].…”

Section: Immunohistochemical Studessupporting

confidence: 64%

Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: Tumor budding as oncotarget

2010

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Epithelial mesenchymal transition (EMT) is proposed as a critical mechanism for the acquisition of malignant phenotypes by epithelial cells. In colorectal cancer, tumor cells having undergone EMT are histologically represented by the presence of tumor buds defined as single cells or small clusters of de-differentiated tumor cells at the invasive front. Tumor budding is not a static, histological feature rather it represents a snap-shot of a dynamic process undertaken by an aggressive tumor with the potential to disseminate and metastasize. Strong, consistent evidence shows that tumor budding is a predictor of lymph node metastasis, distant metastatic disease, local recurrence, worse overall and disease-free survival time and an independent prognostic factor. Moreover, the International Union against Cancer (UICC) recognizes tumor budding as a highly relevant, additional prognostic parameter. The aim of this review is to summarize the evidence supporting the implementation of tumor budding into diagnostic pathology and patient management and additionally to illustrate its worthiness as a potential therapeutic target.

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Budding invasive margin and prognosis in colorectal cancer – no direct association with β-catenin expression

Cited by 36 publications

References 19 publications

Immunohistochemical expression profile of β-catenin, E-cadherin, P-cadherin, laminin-5γ2 chain, and SMAD4 in colorectal serrated adenocarcinoma

Immunohistochemical expression profile of β-catenin, E-cadherin, P-cadherin, laminin-5γ2 chain, and SMAD4 in colorectal serrated adenocarcinoma

Expression of β-Catenin and E-Cadherin, their Clinical Significance and Association with Complexity Index of Colon Carcinoma

Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: Tumor budding as oncotarget

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