Budesonide-liposomes inclusion complex in thermosensitive gel alleviates DSS-induced ulcerative colitis in mice

Yang, Dongliang; Zhao, Yanfang; Li, Teng; He, Jiawei; Zhao, Jun; Gao, Xiaoli; Ma, Guizhi

doi:10.1080/03639045.2023.2212789

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…Furthermore, treatment with methylprednisolone (0.4 mg/day) reduced the colonic inflammatory score and the amount of fecal bacteria in the colon of rats with DSS-induced colitis ( Wang et al, 2011 ). Budesonide was also shown to reduce colitis severity in mice with DSS- and acetic acid-induced colitis, partly through reducing the expression profile of various mediators/cytokines such as myeloperoxidase, nitric oxide, TNF-α, IL-6, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) ( Ali et al, 2014 ; Mishra et al, 2023 ; Seoudi et al, 2023 ; Xian et al, 2023 ; Yang et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Minocycline synergizes with corticosteroids in reducing colitis severity in mice via the modulation of pro-inflammatory molecules

Khajah,

Hawai,

Barakat

et al. 2023

Front. Pharmacol.

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Background: A few studies have highlighted the anti-inflammatory properties of minocycline in reducing colitis severity in mice, but its molecular mechanism is not fully understood. The aim of this study was to determine the anti-inflammatory properties of minocycline and the expression/activity profiles of molecules involved in pro-inflammatory signaling cascades, cytokines, and molecules involved in the apoptotic machinery. The synergistic effect between minocycline and corticosteroids was also evaluated.Methods: The effects of various treatment approaches were determined in mice using the dextran sulfate sodium (DSS) colitis model at gross and microscopic levels. The expression/activity profiles of various pro- or anti-inflammatory molecules were determined using Western blotting and polymerase chain reaction (PCR).Results: Minocycline treatment significantly reduced colitis severity using prophylactic and treatment approaches and produced a synergistic effect with budesonide and methylprednisolone in reducing the active state of colitis. This was mediated in part through reduced colonic expression/activity of pro-inflammatory molecules, cytokines, proteins involved in the apoptotic machinery, and increased expression of the anti-inflammatory cytokine IL-10.Conclusion: Minocycline synergizes with corticosteroids to reduce colitis severity, which could reduce their dose-dependent side effects and treatment cost. The reduction in colitis severity was achieved by modulating the expression/activity profiles of various pro- and anti-inflammatory signaling molecules, cytokines, and molecules involved in the apoptotic machinery.

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Section: Introductionmentioning

confidence: 99%

Minocycline synergizes with corticosteroids in reducing colitis severity in mice via the modulation of pro-inflammatory molecules

Khajah,

Hawai,

Barakat

et al. 2023

Front. Pharmacol.

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Optimising the viscoelastic properties of hyaluronic acid hydrogels through colloidal particle interactions: A response surface methodology approach

Ramanathan,

Hassan,

Rochev

2024

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Optimising the viscoelastic properties of hyaluronic acid hydrogels through colloidal particle interactions: a response surface methodology approach

Ramanathan,

Hassan,

Rochev

2024

Preprint

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Enhancing the viscoelastic characteristics of hydrogel systems through strategic colloidal particle interactions is paramount for their functionality in rectal gel applications. This investigation delves into the synergistic interactions between cationic nanoparticles (CNPs), anionic nanoparticles (ANPs), and composite nanoparticles (NPs) within a hyaluronic acid (HA) hydrogel matrix, employing response surface methodology (RSM) for optimisation. Critical parameters, namely the volume fraction of NPs and oscillatory amplitude, were meticulously calibrated to achieve optimal complex viscosity, as determined by advanced rheometric analysis. The findings reveal substantial effects of CNPs, ANPs, and mixed NPs on the viscoelasticity of the HA hydrogel, with complex viscosity measurements of 490.82 +/- 10.57, 214.70 +/- 8.96, and 328.46 +/- 6.67 mPa.s, respectively. The hydrogel system with mixed NPs exhibited a strong concordance with empirical data (R2 = 0.9843), validating the predictive precision of the model. Morphological assessments uncovered a highly interconnected network within the HA gel-particle composite, characterised by both densely and sparsely packed porous architectures. This study presents a robust framework for modulating viscoelastic properties in colloidal particle-gel systems, providing pivotal insights for the development of advanced rectal gel formulations.

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Budesonide-liposomes inclusion complex in thermosensitive gel alleviates DSS-induced ulcerative colitis in mice

Cited by 3 publications

References 21 publications

Minocycline synergizes with corticosteroids in reducing colitis severity in mice via the modulation of pro-inflammatory molecules

Minocycline synergizes with corticosteroids in reducing colitis severity in mice via the modulation of pro-inflammatory molecules

Optimising the viscoelastic properties of hyaluronic acid hydrogels through colloidal particle interactions: A response surface methodology approach

Optimising the viscoelastic properties of hyaluronic acid hydrogels through colloidal particle interactions: a response surface methodology approach

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