Buerger’s Disease

Dargon, Phong; Landry, Gregory J.

doi:10.1016/j.avsg.2011.11.005

Cited by 79 publications

(65 citation statements)

References 33 publications

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“…Furthermore, thrombosis is believed to play a prominent role in the pathogenesis of TAO (Gaffo, 2013 (Ming-Chao et al, 2008). Until now there has been no effective remedy to cure TAO fundamentally, the poorly clinical treatment for the disease just aims at alleviating the pain of this patients (Dargon and Landry, 2012;Vijayakumar et al, 2013). TAO belongs to "gangrene" category of traditional Chinese medicine.…”

Section: Introductionmentioning

confidence: 99%

“…Thromboangiitis obliterans (TAO) is a chronic nonatherosclerotic segmental occlusive vasculitis with arterial lumen thrombosis, which most commonly involves the small-and medium-sized arteries and veins of the extremities and usually leads to gangrene and tissue loss (Hong et al, 2011;Dargon and Landry, 2012;Weinberg and Jaff, 2012;Vijayakumar et al, 2013). At present, TAO accounted for 40-60% of peripheral vascular diseases in eastern parts of the world.…”

Section: Introductionmentioning

confidence: 99%

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Shenfu injection protects human ECV304 cells from hydrogen peroxide via its anti-apoptosis way

Hong

Guo

Zhou³

et al. 2015

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Shenfu injection protects human ECV304 cells from hydrogen peroxide via its anti-apoptosis way

Hong

Guo

Zhou³

et al. 2015

Journal of Ethnopharmacology

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“…Although commonly accepted diagnostic criteria are still unavailable, nowadays, the most used are Shionoya's criteria (1)(2)(3). Discontinuation of tobacco is the cornerstone of therapy.…”

Section: Introductionmentioning

confidence: 99%

“…Discontinuation of tobacco is the cornerstone of therapy. Other forms of treatment, including vasodilators (prostaglandin analogs and calcium channel blockers), have all been tried, with limited effect in decreasing pain and avoiding amputation (1)(2)(3).…”

Section: Introductionmentioning

confidence: 99%

Nailfold capillaroscopy in Buerger’s disease: A useful tool?

Guidelli¹,

Bardelli²,

Fioravanti³

et al. 2014

Eur J Rheumatol

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Thromboangiitis obliterans (TAO, or Buerger's disease) is a rare inflammatory vasculitis that commonly involves small and medium-sized arteries of the extremities of tobacco smokers between the ages of 25 and 50 years. Although the diagnosis is based on the clinical picture and angiographic findings, we studied the microvascular involvement by nailfold capillaroscopy. We evaluated by nailfold capillaroscopy 2 patients with Buerger's disease, at baseline and after 6 months of tobacco discontinuation and therapy with prostanoids. Both patients presented similar capillaroscopic abnormalities, resembling a scleroderma-like pattern. The microvascular rearrangement was significantly reduced after 6 months of evaluation. The capillaroscopic abnormalities shown in the two patients could be related to thromboangiitis obliterans, and nailfold capillaroscopy could be a useful tool to evaluate disease progression and the response to treatment.Key words: Thromboangiitis obliterans, nailfold capillaroscopy, acral skin ulcers IntroductionThromboangiitis obliterans (TAO, or Buerger's disease) is a relatively rare segmental non-atherosclerotic inflammatory disorder of peripheral blood vessels, affecting small and medium-sized arteries and veins of the extremities. Exposure to tobacco is central to the initiation, maintenance, and progression of the disease (1).Although commonly accepted diagnostic criteria are still unavailable, nowadays, the most used are Shionoya's criteria (1-3). Discontinuation of tobacco is the cornerstone of therapy. Other forms of treatment, including vasodilators (prostaglandin analogs and calcium channel blockers), have all been tried, with limited effect in decreasing pain and avoiding amputation (1-3).Patients may present with early findings of pain or coldness in the fingers and Raynaud phenomenon (RP), followed by rest pain and acral skin ulcers (3).Nailfold capillaroscopy (NFC) is a simple and non-invasive technique that allows the in vivo assessment of the microvascular environment, and it has been demonstrated to be helpful in the differential diagnosis of some diseases, primarily capable of differentiating between primary and secondary RP, systemic sclerosis (SSc), and dermatomyositis (4-6).Since TAO is a vasculitic syndrome characterized by small and medium vessel involvement, often associated with acral ulcers, the aim of our preliminary study was to investigate whether NFC could represent a tool in the diagnosis and follow-up of the disease during the acute phase and over a 6-month follow-up. Case PresentationWe evaluated two male patients who were referred to our outpatient clinic for RP and painful acral ulcers. The first patient, a 48-year-old man, presented with a 5-week history of pain in his hands and feet, ulcerations, and digital gangrene, which was associated with blue discoloration and claudication of both feet.He was a lifelong heavy smoker (about 20 cigarettes/day since 20 years) but had no other cardiovascular risk factors. He had a history of RP affecting both hands for ...

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“…n INTRODUCTION T hromboangiitis obliterans (TAO), also known as Buerger's disease, is a segmental vasculitis of small and mediumsized arteries causing obstruction of blood vessels (1). The average age of onset is around 40-45 years, and males are more frequently affected (2).…”

mentioning

confidence: 99%

Coexistence of axial spondyloarthritis and thromboangiitis obliterans in a young woman

Lopalco¹,

Iannone²,

Rigante

et al. 2015

Reumatismo

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A peculiar coexistence of axial spondyloarthritis and ischemia of the feet and the fourth finger of the left hand in a young woman, who was a heavy smoker, is discussed in this report. This picture was considered within the context of thromboangiitis obliterans. Positivity of anti-nuclear antibodies and mild elevation of inflammatory parameters were noted. Computed tomography angiograms of upper and lower limbs showed luminal narrowing and occlusion of the left humeral, left anterior/posterior tibial and right anterior tibial arteries. Daily iloprost perfusions were started, and smoking cessation was strongly recommended. Coldness and rest pain in the distal extremities improved within a few weeks. The possibility that spondyloarthritis might precede the clinical picture of thromboangiitis obliterans should be considered in heavy smokers.

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Buerger’s Disease

Cited by 79 publications

References 33 publications

Shenfu injection protects human ECV304 cells from hydrogen peroxide via its anti-apoptosis way

Shenfu injection protects human ECV304 cells from hydrogen peroxide via its anti-apoptosis way

Nailfold capillaroscopy in Buerger’s disease: A useful tool?

Coexistence of axial spondyloarthritis and thromboangiitis obliterans in a young woman

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