Bufadienolide ausUrginea pancration¹

Abstract

From bulbs of URGINEA PANCRATION (Steinh.) G. de Philippe (Hyacinthaceae) 5 bufadienolides were isolated by a combination of column and droplet counter-current chromatography; their structures were elucidated mainly by FAB-MS and (1)H- and (13)C-NMR spectroscopy. Besides the already known scilliglaucoside ( 1), scillirubroside ( 2), and scilliroside ( 3), two new bufadienolides were identified: 5alpha-4,5-dihydroscillirosidin- 3beta- O-alpha- L-thevetosido-4'-beta- D-glucopyranoside and arenobufagin-3beta- O- L-rhamnopyranosido-4'-beta- D-glucopyranoside.

Zum Bufadienolidmuster der roten „Meerzwiebel”1

“…In the bulbs from Sardegna scillaren A (3), gamabufotahri 3-O-a-L-rhamnoside (20), scilliglaucoside (17), sdillirubrosidiii 3-O-a-L-rhamnoside (11), scillirubroside (12), 12/3-hydroxysciffiroside (15), 5a-4,5-dihydroscilirosidin 3-O-a-L-thevetosido-/3-D-glucoside (19), and deacetylscilliroside (8) besides the new compounds 1O-carboxy-5J3, 1 4J3-dihydroxybufa-3,20,22-trienolide S-O-/3-Dglucoside (18) and scffliglaucogenin (16) were found in addition. Not only quantitative but even qualitative differences in the bufadienolide pattern between the samples of the northern and the southern Mediterranean area were proved.…”

Simultaneous determination of bufadienolides and phenolic compounds in sea squill (Drimia maritima (L.) Stearn) by HPLC-DAD-MSn as a means to differentiate individual plant parts and developmental stages

“…Further, bufadienolides, which have been found in red sea squill from North Africa [11], were detected in our investigations (B2, B8, B12, B13, B25). In addition, bufadienolide B3 was found in a diploid, white sea squill, harvested in Southern Italy [33]. Bufadienolides B28 and B35 were detected in an U. maritima sample, the origin of which has not been described in detail [34].…”

Bufadienolide ausUrginea maritima sensu strictu1

“…8 ppm nach hOherem Feld verschoben (16). Da eine eindeutige Zuordnung der Signale der C-Atome 1,2,5,6, 7 und 8 aufgrund von Inkrementberechung Obwohl die Hauptmenge der herzw!rksamen Verbindungen auf Glykoside des Scillarenins (1)(2)(3) und Scilliphaosidins (4-6) sowie auf Scullicyanosid (8) entfällt, stellen 5a-4,5-Dihydro-prosc!llaridin A (12), 5a-4,5-Dihydro-glucoscillaren A (13) und 19-Oxo-5a-4,5-dihydroproscillaridin A (14) keine Nebenkomponenten dar, sondern kOnnen bis zu 10 Prozent an der Gesamtbufadienol!dkonzentration beteil!gt sein (2).…”