Bufavirus in fecal specimens of patients with and without diarrhea in Thailand

Chieochansin, Thaweesak; Vutithanachot, Viboonsak; Theamboonlers, Apiradee; Poovorawan, Yong

doi:10.1007/s00705-015-2441-z

Cited by 31 publications

(32 citation statements)

References 14 publications

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“…In the stool samples, we found a low BuV-DNA prevalence in Finnish children presenting with acute gastroenteritis with or without respiratory tract infection, in line with prior reports1591011. We observed for the first time BuV DNA in a nasal swab, albeit at a very low quantity, and with no BuV IgG nor DNA detectable in a corresponding serum.…”

Section: Discussionsupporting

confidence: 91%

“…Until now, human bufaviruses, mostly BuV1 or BuV3, has been detected by PCR in several geographical locations in Africa, Europe and Asia; but exclusively in diarrheal stools157891011. Studies have not included other sample types or other diagnostic means, yet the closely related BuV-like viruses have been found in spleens or sera of infected animals, indicating systemic infections1213.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence in patients has been low, 0.3% to 4%, and although in three publications stool samples from non-diarrheic patients or healthy subjects were shown to be BuV-DNA negative91011, the etiological role of the virus in diarrhoea or in other human diseases remains uncertain.…”

mentioning

confidence: 99%

“…To date, bufavirus has been searched for exclusively in stool samples, and it has been detected in diarrheal stools of children and adults in Africa, Europe and Asia, including Burkina Faso, Tunisia, Bhutan, Finland, the Netherlands, Thailand, Turkey and China157891011. The prevalence in patients has been low, 0.3% to 4%, and although in three publications stool samples from non-diarrheic patients or healthy subjects were shown to be BuV-DNA negative91011, the etiological role of the virus in diarrhoea or in other human diseases remains uncertain.…”

mentioning

confidence: 99%

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Epidemiology of two human protoparvoviruses, bufavirus and tusavirus

Väisänen

Paloniemi

Kuisma

et al. 2016

Sci Rep

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Two human parvoviruses were recently discovered by metagenomics in Africa, bufavirus (BuV) in 2012 and tusavirus (TuV) in 2014. These viruses have been studied exclusively by PCR in stool and detected only in patients with diarrhoea, although at low prevalence. Three genotypes of BuV have been identified. We detected, by in-house EIA, BuV1-3 IgG antibodies in 7/228 children (3.1%) and 10/180 adults (5.6%), whereas TuV IgG was found in one child (0.4%). All children and 91% of the adults were Finnish, yet interestingly 3/6 adults of Indian origin were BuV-IgG positive. By competition EIA, no cross-reactivity between the BuVs was detected, indicating that the BuV genotypes represent distinct serotypes. Furthermore, we analysed by BuV qPCR stool and nasal swab samples from 955 children with gastroenteritis, respiratory illness, or both, and found BuV DNA in three stools (0.3%) and for the first time in a nasal swab (0.1%). This is the first study documenting the presence of BuV and TuV antibodies in humans. Although the seroprevalences of both viruses were low in Finland, our results indicate that BuV infections might be widespread in Asia. The BuV-specific humoral immune responses appeared to be strong and long-lasting, pointing to systemic infection in humans.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Epidemiology of two human protoparvoviruses, bufavirus and tusavirus

Väisänen

Paloniemi

Kuisma

et al. 2016

Sci Rep

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“…To date, scientists have searched for bufaviruses almost exclusively in fecal samples and have detected them in diarrheal stools of patients of all ages worldwide. The prevalence of bufaviruses in human patients ranges from 0.3% to 4%, and their etiologic role in enteric or extraenteric diseases remains uncertain (16,17,(37)(38)(39)(40)(41). Bufaviruses have also been found in other mammalian hosts, including wild and captive nonhuman primates, swine, shrews, rats, bats, and fur seals (18)(19)(20)(42)(43)(44)(45)(46).…”

Section: Novel Parvovirus In Dogsmentioning

confidence: 99%

Novel Parvovirus Related to Primate Bufaviruses in Dogs

Martella¹,

Lanave²,

Mihalov-Kovács³

et al. 2018

Emerg. Infect. Dis.

125

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A novel protoparvovirus species, related genetically to human bufaviruses, was identified in dogs with respiratory signs. The canine bufavirus was distantly related to the well-known canine protoparvovirus, canine parvovirus type 2, sharing low amino acid identities in the nonstructural protein 1 (40.6%) and in the capsid protein 1 (33.4%). By screening collections of fecal, nasal, and oropharyngeal samples obtained from juvenile dogs (<1 year of age), canine bufavirus DNA appeared as a common component of canine virome. The virus was common in the stool samples of dogs with or without enteric disease and in the nasal and oropharyngeal swab samples of dogs with respiratory signs. However, the virus was not detected in nasal and oropharyngeal swab samples from animals without clinical signs.

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Parvovirus B19V, Bocaviruses, and Other Human Parvoviruses

Söderlund‐Venermo

2023

ClinMicroNow

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Parvoviruses are small, nonenveloped icosahedral viruses with a linear single‐stranded‐DNA (ssDNA) genome in the family Parvoviridae in the realm Monodnaviria . The family Parvoviridae is divided into three subfamilies, Parvovirinae , Densovirinae , and the new Hamaparvovirinae , on the basis of their ability to infect vertebrates, invertebrates, or both, respectively, and their NS1 amino acid sequences. The first human parvoviruses identified were the nonpathogenic adeno‐associated viruses of the genus Dependoparvovirus , which are increasingly used in gene therapy. Human bocavirus (HBoV1) has the typical structure of a member of the Parvoviridae . The most common test for diagnosis of HBoV1 infection is DNA detection by qualitative PCR. Parvoviruses are unable to induce cells to divide, so they require actively dividing cells for their replication.

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Bufavirus in fecal specimens of patients with and without diarrhea in Thailand

Cited by 31 publications

References 14 publications

Epidemiology of two human protoparvoviruses, bufavirus and tusavirus

Epidemiology of two human protoparvoviruses, bufavirus and tusavirus

Novel Parvovirus Related to Primate Bufaviruses in Dogs

Parvovirus B19V, Bocaviruses, and Other Human Parvoviruses

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