“…As for branched short-chain fatty acids, isobutyric, 2-methylbutyric, and 3-methylbutyric acids, collectively called isoacids, are efficiently produced in the rumen by deamination and subsequent decarboxylation of valine, isoleucine, and leucine, respectively, which come largely from dietary protein digestion . Then VFA and isoacids, produced in the rumen, are rapidly absorbed in the blood by action of specific carriers of the family of the monocarboxylate transporters present on the epithelium of various tracts of the animal’s gastrointestinal tract and used by body tissues for lipid biosynthesis, gluconeogenesis, or milk formation. − Given the richness of buffalo milk composition, showing health properties different from those of cow milk, because it possesses a low-allergenic potential and provides benefits for obesity, hypertension, and osteoporosis, an increase of knowledge regarding the natural substance content could be useful to drive the dairy industry toward the production of buffalo milk and buffalo milk-based products with improved nutritional properties. The presence of δ-VB, recently described in cattle, goat, and sheep milk, opened a new scenario about the ruminant metabolite with important roles in animal physiology and consumers’ health .…”