Buffered 2% articaine versus non-buffered 4% articaine in maxillary infiltration: randomized clinical trial

Amorim, Klinger de Souza; Fontes, Vanessa Tavares Silva; Gercina, Anne Caroline; Groppo, Francisco Carlos; Souza, Rafael Gomes de

doi:10.1007/s00784-020-03674-x

Cited by 8 publications

(31 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In order to make feasible their injection, these bases are combined with hydrochloric acid to form local anaesthetic salt, in which form they are quite soluble in water and comparatively stable, becoming mostly a solution with an approximate pH of 5.9. 1 Usually, epinephrine is added into local anesthetics solution at a ratio of 1:100,000 or 1:200,000 to balance blood vessel dilatation, leading to blood vessel constriction at the site of application, prolonging anaesthesia duration. However, the sodium bisulphite is added as an antioxidant to stabilize that kind of vasoconstrictor, which makes the solution even more acidic (pH approximately 3.5).…”

Section: Discussionmentioning

confidence: 99%

“…Injection of these acidic solutions may consequently present negative effects, such as burning, some degree of tissue injury, relatively slow-onset anaesthesia, and unsatisfactory activity in the presence of infection and inflammation (even lower pH). 1 To compensate for the low pH, the organism itself performs a physiological buffering mechanism, which takes time and directly influences the onset of local anaesthetic action. 1 Another alternative for changing the pH of the local anaesthetic solution is to buffer it with sodium bicarbonate.…”

Section: Discussionmentioning

confidence: 99%

“…1 To compensate for the low pH, the organism itself performs a physiological buffering mechanism, which takes time and directly influences the onset of local anaesthetic action. 1 Another alternative for changing the pH of the local anaesthetic solution is to buffer it with sodium bicarbonate. Increasing the pH of the solution to the approximate to physiological pH (around 7.4) can result in the elimination of injection burning, reduction of tissue injury, and onset time.…”

Section: Discussionmentioning

confidence: 99%

“…Gastroesophageal reflux is a common phenomenon in infants, but the differentiation between gastroesophageal reflux and gastroesophageal reflux disease can be difficult. 1 Symptoms of reflux are non-specific, and there is increasing evidence that the majority of symptoms may not be acid-related. In children with infant gastroesophageal reflux symptoms, clinical improvement has been suggested following a frenotomy of a tongue-tie.…”

mentioning

confidence: 99%

“…In children with infant gastroesophageal reflux symptoms, clinical improvement has been suggested following a frenotomy of a tongue-tie. 1 Slagter and colleagues (2021) 1 reported on a longitudinal study that sought to assess Breastfeeding and Reflux Improvement by the Efficacy of a Frenotomy (BRIEF) in infants with breastfeeding problems up to 6 months after treatment. Breastfeeding self-efficacy for mothers was used as the primary outcome measure.…”

mentioning

confidence: 99%

See 4 more Smart Citations

What’s new for the clinician? - Excerpts from and summaries of recently published papers

Yengopal¹

2021

S. Afr. dent. j.

View full text Add to dashboard Cite

The World Health Organization (WHO) considers breast milk as the best source of nourishment for infants. Although exclusive breastfeeding is recommended up to 6 months of age, globally only 40% of children under this age are exclusively breastfed and this is mainly due to negative breastfeeding experiences. There are many different causes for negative breastfeeding experiences such as poor weight gain, necessitating supplementation, poor latch, maternal nipple pain, and oral restrictions like a tongue-tie (ankyloglossia) and/or lip-tie. Ankyloglossia (either the decrease in mobility for the tongue by classic anterior tongue-tie or a submucosal restriction, a posterior tongue-tie) and a superior tethered labial frenulum can cause altered latch and sucking mechanics. Studies have shown that a frenotomy, if adequately performed, can improve breastfeeding scores and relieve nipple pain with little or no serious complications.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

What’s new for the clinician? - Excerpts from and summaries of recently published papers

Yengopal¹

2021

S. Afr. dent. j.

View full text Add to dashboard Cite

show abstract

Buffered 2% articaine in buccal infiltration of mandibular molars: a randomized triple-blind clinical trial

LOAYZA,

BARBIN,

SANTOS

et al. 2023

Braz. oral res.

Self Cite

View full text Add to dashboard Cite

This crossover study aimed to compare the anesthetic effects of buffered 2% articaine with 1:200,000 epinephrine with that of non-buffered 4% articaine with 1:200,000 epinephrine. Forty-seven volunteers were administered two doses of anesthesia in the buccal region of the second mandibular molars in two sessions using 1.8 mL of different local anesthetic solutions. The onset time and duration of pulp anesthesia, soft tissue pressure pain threshold, and the score of pain on puncture and burning during injection were evaluated. The operator, volunteers, and statistician were blinded. There were no significant differences in the parameters: onset of soft tissue anesthesia (p = 0.80), duration of soft tissue anesthesia (p = 0.10), onset of pulpal anesthesia in the second (p = 0.28) and first molars (p = 0.45), duration of pulp anesthesia of the second (p = 0.60) and first molars (p = 0.30), pain during puncture (p = 0.82) and injection (p = 0.80). No significant adverse events were observed. Buffered 2% articaine with 1:200,000 epinephrine did not differ from non-buffered 4% articaine with 1:200,000 epinephrine considering anesthetic success, safety, onset, duration of anesthesia, and pain on injection.

show abstract

Buffered articaine infiltration for primary maxillary molar extractions: a randomized controlled study

Dhake

Nagpal

Chaudhari

et al. 2022

J Dent Anesth Pain Med

View full text Add to dashboard Cite

Background Dental pain management is an important aspect of patient management in pediatric dentistry. Articaine is considered the most successful anesthetic agent for infiltration anesthesia. Buffered articaine has been observed to have faster onset and longer duration of action with less pain on injection. The aim of this study was to evaluate and compare pain on injection, onset of action, and pain during extraction using buffered (using Sodium bicarbonate (NaHCO 3 )) and non-buffered 4% articaine (with 1:100000 adrenaline) infiltrations for primary maxillary molar extractions in 4–10-year-old children. Methods Seventy children who required extraction of maxillary primary molars were enrolled in this triple-blind randomized study. Children undergoing extraction were randomly divided into two groups, with 35 in each group. The study group was the buffered articaine group; the control group was the non-buffered articaine group. Buccal and palatal infiltrations were administered with either buffered or non-buffered articaine. Subjective evaluation was done for pain on injection, pain during extraction using Wong–Baker Faces Pain Rating Scale (WBFPR) and onset of anesthesia in seconds. Pain on injection, pain during extraction were objectively evaluated using Sound Eye Motor (SEM) scale and onset of anesthesia was also evaluated objectively by pricking with sharp dental probe. Results The outcome was, significantly less pain on injection and significantly faster onset of anesthesia with significantly less pain during extraction for both subjective and objective evaluations in the buffered articaine group. Subgroup analysis was also performed and it showed variable results, with only significant difference for WBFPR scores in age subgroup 4–7 years for palatal infiltration. Conclusion Less pain on injection, faster onset of anesthesia, and less pain during extraction were observed when buffered articaine was used for maxillary primary molar extraction.

show abstract

Buffered 2% articaine versus non-buffered 4% articaine in maxillary infiltration: randomized clinical trial

Cited by 8 publications

References 19 publications

What’s new for the clinician? - Excerpts from and summaries of recently published papers

What’s new for the clinician? - Excerpts from and summaries of recently published papers

Buffered 2% articaine in buccal infiltration of mandibular molars: a randomized triple-blind clinical trial

Buffered articaine infiltration for primary maxillary molar extractions: a randomized controlled study

Contact Info

Product

Resources

About