Bufotenines-loaded liposome exerts anti-inflammatory, analgesic effects and reduce gastrointestinal toxicity through altering lipid and bufotenines metabolism

Lipids are biological molecules that play vital roles in all living organisms. They perform many cellular functions, such as 1) forming cellular and subcellular membranes, 2) storing and using energy, and 3) serving as chemical messengers during intra‐ and inter‐cellular signal transduction. The large‐scale study of the pathways and networks of cellular lipids in biological systems is called “lipidomics” and is one of the fastest‐growing omics technologies of the last two decades. With state‐of‐the‐art mass spectrometry instrumentation and sophisticated data handling, clinical studies show how human lipid composition changes in health and disease, thereby making it a valuable medium to collect for clinical applications, such as disease diagnostics, therapeutic decision‐making, and drug development. This review gives a comprehensive overview of current workflows used in clinical research, from sample collection and preparation to data and clinical interpretations. This is followed by an appraisal of applications in 2022 and a perspective on the exciting future of clinical lipidomics.

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“…Bibliometric analyses of clinical lipidomics publications in 2022 according to separation techniques, detectors, and RPLC columns used …”

Section: In Review: Materials and Methodsmentioning

confidence: 99%

“…Bibliometric analyses of clinical lipidomics publications in 2022 using Scopus search terms “lipidomics” AND “clinic*” on 15 th December 2022 …”

Section: In Review: Materials and Methodsmentioning

confidence: 99%

Chewing the fat: How lipidomics is changing our understanding of human health and disease in 2022

Géhin

Fowler

Trivedi

2023

Analytical Science Advances

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“… 79 Furthermore, the use of liposomes as drug carriers enables transmembrane transport and provides selective passive targeting of tumor tissues. 80 , 81 Shen et al 53 prepared bufotenines liposomes with mean particle size, PDI and zeta potential of (130.1 ± 4.06) nm, 0.217 and (−8.00 ± 0.88) mV, respectively. The anti-inflammatory and analgesic effects of drug-loaded liposomes were proved by formalin-induced inflammatory pain behavior and hot plate experiments.…”

Section: Passive Targeted Drug Delivery Systemmentioning

confidence: 99%

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Zhang,

Zhai,

Sun

et al. 2024

IJN

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Dried toad skin (TS) and toad venom (TV) are the dried skin of the Bufo bufo gargarizans Cantor and the Bufo melanostictus Schneider , which remove the internal organs and the white secretions of the skin and retroauricular glands. Since 2005, cinobufacini preparations have been approved by the State Food and Drug Administration for use as adjuvant therapies in the treatment of various advanced cancers. Meanwhile, bufalenolides has been identified as the main component of TS/TV, exhibiting antitumor activity, inducing apoptosis of cancer cells and inhibiting cancer cell proliferation or metastasis through a variety of signaling pathways. However, clinical agents frequently face limitations such as inherent toxicity at high concentrations and insufficient tumor targeting. Additionally, the development and utilization of these active ingredients are hindered by poor water solubility, low bioavailability, and rapid clearance from the bloodstream. To address these challenges, the design of a targeted drug delivery system (TDDS) aims to enhance drug bioavailability, improve targeting within the body, increase drug efficacy, and reduce adverse reactions. This article reviews the TDDS for TS/TV, and their active components, including passive, active, and stimuli-responsive TDDS, to provide a reference for advancing their clinical development and use.

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Liposomes as sustainable delivery systems in food, cosmetic, and pharmaceutical applications

Luo,

Oomah,

Akoetey

et al. 2024

J Americ Oil Chem Soc

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Liposomes are artificial microscopic vesicles composed of phospholipid bilayers with the ability to encapsulate both hydrophobic and hydrophilic molecules, owing to the amphipathic nature of lipids. Hydrophobic molecules can be stored within the bilayer membrane, while hydrophilic molecules can be embedded in the inner core of liposomes. Encapsulated compounds within liposomes are protected from environmental and chemical alterations, such as enzymatic and chemical modifications, as well as changes against extreme pH, temperature, and ionic strength. Liposomes protective nature highlights their importance as nanocarriers for a wide spectrum of hydrophobic and hydrophilic molecules. This review offers a concise introduction to the fundamental physicochemical properties of liposomes and the various production methods including the role of cholesterol and potential alternatives such as phytosterols. It also provides an up‐to‐date overview of liposomes applications as delivery vehicles in food, cosmetics, and pharmaceuticals.

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Bufotenines-loaded liposome exerts anti-inflammatory, analgesic effects and reduce gastrointestinal toxicity through altering lipid and bufotenines metabolism

Cited by 6 publications

References 42 publications

Chewing the fat: How lipidomics is changing our understanding of human health and disease in 2022

Chewing the fat: How lipidomics is changing our understanding of human health and disease in 2022

Advances on Delivery System of Active Ingredients of Dried Toad Skin and Toad Venom

Liposomes as sustainable delivery systems in food, cosmetic, and pharmaceutical applications

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