With the recent revolution in the green economy, agricultural solid waste resource utilization has become an important project. A small-scale laboratory orthogonal experiment was set up to investigate the effects of C/N ratio, initial moisture content and ll ratio (v cassava residue : v gravel ) on the maturity of cassava residue compost by adding Bacillus subtilis and Azotobacter chroococcum. The highest temperature in the thermophilic phase of the low C/N ratio treatment is signi cantly lower than the medium and high C/N ratios. The C/N ratio and moisture content have a signi cant impact on the results of cassava residue composting, while the lling ratio only has a signi cant impact on the pH value and phosphorus content. Based on comprehensive analysis, the recommended process parameters for pure cassava residue composting are a C/N ratio of 25, an initial moisture content of 60%, and a lling ratio of 5. Under these conditions, the high-temperature conditions can be reached and maintained quickly, the organic matter has been degraded by 36.1%, the pH value has dropped to 7.36, the E4/E6 ratio is 1.61, the conductivity value has dropped to 2.52 mS/cm, and the nal germination index increased to 88%. The thermogravimetry, scanning electron microscope, and energy spectrum analysis also showed that the cassava residue was effectively biodegraded. Cassava residue composting with this process parameter has great reference signi cance for the actual production and application of agriculture.