The Ghanaian construction industry faces challenges in managing safety, especially for small and medium-sized enterprises (SMEs) that need more resources. This research addressed the critical need for a positive safety culture framework specifically designed for SMEs in Ghana. The study adopts the Delphi research approach, which involves a series of questionnaire ‘rounds’ to gather and refine information and develop a collaborative safety culture framework with SME stakeholders. The study employed a mixed-methods strategy, harnessing quantitative and qualitative data to meet the research goals. The critical components of the developed framework included safety commitment, adaptability, information, awareness, culture, and performance. The research offered evidence-based recommendations for effective positive safety practices across Ghana’s SMEs by analysing the relationship between these interventions and safety outcomes. Applying the framework should reduce workplace accidents and foster a positive safety culture that aligns with international best practices.