1981
DOI: 10.1080/00304948109356498
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Building Blocks for the Synthesis of Maytansinoids

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1981
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Cited by 9 publications
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“…Gotschi et al [ 103 ] have synthesized the correctly substituted aromatic portion of maytansine, as well as its C9 to C15 moiety. The synthesis was initiated from the ethyl vanillate derivative ( 352 ) via the aldehyde ( 3 53 ).…”
Section: Chemical Synthesis Of Maytansine and Maytansine Fragmentsmentioning
confidence: 99%
“…Gotschi et al [ 103 ] have synthesized the correctly substituted aromatic portion of maytansine, as well as its C9 to C15 moiety. The synthesis was initiated from the ethyl vanillate derivative ( 352 ) via the aldehyde ( 3 53 ).…”
Section: Chemical Synthesis Of Maytansine and Maytansine Fragmentsmentioning
confidence: 99%
“…A similar Stern-Volmer slope (kqr = 181 ± 2 M-1) for fluorescence quenching by DMB suggests that the latter quenches only the excited singlet state of DCA. The oxidation potential (Eox¡/2 = 1.55 V vs. SCE)15 of 1 indicates, however, that 1+• should be quenched by DMB (E0*^= 1.34 V vs. SCE)16 at a near diffusion (10) The expected hyperfine coupling at H(l) and H(2) in the radical cation 1+• is supported by analogy with that of 9,10-bis [(trimethylsilylmethyl)]-9,10-dihydroanthracene (i) radical cation (aho) = 0.074 mT, aH(2) = 0.319 mT: Kam. W.; Bock, H. Chem.…”
mentioning
confidence: 99%