Building information modeling (BIM) has received significant attention in the last two decades from the architecture, engineering, and construction (AEC) industry. Despite the popular trend of BIM in developing countries, the adoption of this technology is still low. This paper aims to investigate the drivers, barriers, and enablers of BIM adoption in developing countries with regard to global challenges. A systematic literature review and an in-depth comparative qualitative analysis were conducted to accomplish the objective. Relevant articles from three major databases covering 20 years (2002–2022) of journal article publications were analyzed. The comparative study identified drivers, barriers, and enablers influencing BIM innovation in six developing countries from three different continents. Additionally, a critical review and analysis explored the importance of BIM’s innovation factors in developing countries. The stakeholders of AEC will benefit from insights offered by this study to prepare BIM implementation strategies effectively.