The health and well‐being of migrant workers struggling to make ends meet are being compromised, especially with the uncertainty of the COVID‐19 pandemic. The aim is to analyze how organizational empowerment promotes health and well‐being from an applied psychological perspective, taking into account the shaping role of individual vulnerability. Links between theory and practice will be established to achieve equitable health and well‐being. The underlying mechanism by which organizational empowerment mitigated workplace‐induced adverse outcomes was validated in the analysis of construction workers (n = 966). In addition, individual characteristics, namely, excitability, low perceptual threshold, control, and knowledge, attitude, and practice, were identified as critical factors, as well‐being consequences vary from person to person. Moderating effect analysis showed that high excitability enhanced the association between work environment exposure and health and well‐being. Control and knowledge, attitude, and practice have opposite effects. Moreover, the dual effects of the low perception threshold are verified, that is, facing the work environment produces more negative consequences, whereas perceiving more resources stimulates more positive consequences. Overall, the research provides a clearer dialectical view of vulnerability, contributing wisdom toward accurate management based on empowerment theory, which lays a solid foundation for bridging gaps in health and well‐being.