A new method is developed to analyze CANDLE (Constant Axial shape of Neutron flux, nuclide densities and power shape During Life of Energy producing reactor) burnup, where the microscopic group cross-sections are evaluated at every space mesh by TLLI (Table Look-up and Linear Interpolation) method, and used to analyze a fast reactor with natural uranium as a fresh fuel. The results are compared with the conventional method, where only one set of the microscopic group cross-sections is employed, to investigate the effects of space-dependency of the microscopic group cross-sections and feasibility of the old method. The differences of the effective neutron multiplication factor, burning region moving speed, spent fuel burnup and spatial distributions of nuclide densities, neutron fluence and power density may be considerable from the reactor designer point. However, they are small enough when we study about the characteristics of CANDLE burnup for different designs.