2024
DOI: 10.1073/pnas.2315992121
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Building on-chip cytoskeletal circuits via branched microtubule networks

Meisam Zaferani,
Ryungeun Song,
Sabine Petry
et al.

Abstract: Controllable platforms to engineer robust cytoskeletal scaffolds have the potential to create novel on-chip nanotechnologies. Inspired by axons, we combined the branching microtubule (MT) nucleation pathway with microfabrication to develop “cytoskeletal circuits.” This active matter platform allows control over the adaptive self-organization of uniformly polarized MT arrays via geometric features of microstructures designed within a microfluidic confinement. We build and characterize basic elements, including … Show more

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