Building Organs Using Tissue-Specific Microenvironments: Perspectives from a Bioprosthetic Ovary

Henning, N; Jakus, Adam E.; Laronda, Monica M.

doi:10.1016/j.tibtech.2021.01.008

Cited by 12 publications

(11 citation statements)

References 109 publications

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“… 186 To generate optimal microenvironments that can recapitulate in vivo folliculogenesis, precise spatial mapping of biochemical and mechanical properties in whole ovaries in vivo is required. 187 Next, we need to determine which signals are required to maintain dormancy versus activate primordial follicles. 187 New culture methods as well as 3D scaffolds will be required to establish long‐term culture of 3D ovarian folliculogenesis models in large non‐rodent animals.…”

Section: Discussion—perspectives and Challengesmentioning

confidence: 99%

“… 187 Next, we need to determine which signals are required to maintain dormancy versus activate primordial follicles. 187 New culture methods as well as 3D scaffolds will be required to establish long‐term culture of 3D ovarian folliculogenesis models in large non‐rodent animals. 187 The recent development of 3D printed bioprosthetic ovaries in mice showed 3D bio‐printed scaffolds as promising tools for the development of 3D ovarian folliculogenesis models.…”

Section: Discussion—perspectives and Challengesmentioning

confidence: 99%

“… 187 , 206 , 207 Previous studies showed that synthetic hydrogels are a useful tool to investigate the effects of ECM stiffness on cell function. 155 , 156 , 157 However, naïve ECMs are viscoelastic and thus exhibit stress relaxation.…”

Section: Discussion—perspectives and Challengesmentioning

confidence: 99%

“…22 Furthermore, given the importance of cell-ECM interactions, a major technological challenge is to develop in vitro ECM tools that mimic both normal and pathological ECM in the female, reproductive system in vivo. 187,206,207 Previous studies showed that synthetic hydrogels are a useful tool to investigate the effects of ECM stiffness on cell function. [155][156][157] However, naïve ECMs are viscoelastic and thus exhibit stress relaxation.…”

Section: Experimental Toolsmentioning

confidence: 99%

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Mechanobiology of the female reproductive system

Matsuzaki

2021

Reprod Medicine & Biology

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The field of mechanobiology focuses on how the responses of cells, tissues, and organs to mechanical cues, resulting from both intracellularly generated and externally generated forces, contribute to development, differentiation, physiology and disease via the integration of medicine, biology, engineering, and physics. [1][2][3] How living cells can sense their environment and adequately respond in terms of morphology, migration, proliferation, differentiation, and survival requires understanding at multiple scales, from molecules to single cells, tissues, and organs. [1][2][3] More than a century ago, mechanical forces were proposed to drive embryogenesis and bone structure. [1][2][3] The importance of mechanical forces for biological regulation was recognized in the field of developmental biology at the beginning of the twentieth century. [1][2][3] However, there were no experimental tools available to directly test

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Section: Discussion—perspectives and Challengesmentioning

confidence: 99%

Section: Discussion—perspectives and Challengesmentioning

confidence: 99%

Section: Discussion—perspectives and Challengesmentioning

confidence: 99%

Section: Experimental Toolsmentioning

confidence: 99%

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Mechanobiology of the female reproductive system

Matsuzaki

2021

Reprod Medicine & Biology

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“…The conception of 3D manufacturing of biomedical materials and devices could be the solution to the problem and get a rise in the last years 1,[3][4][5][6] . 3D manufacturing approaches in microgravity conditions offer several signi cant capabilities for space exploration that can be exploited 7,8 . The possibility to produce tissue engineering constructs have been become reality.…”

Section: Introductionmentioning

confidence: 99%

Manufacturing bone tissue in space destined for patients on Earth?

Parfenov

Zobkov

Каралкин

et al. 2023

Preprint

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Space exploration is perhaps one of the most difficult tasks ever undertaken since the existence of mankind. International Space Station (ISS) is a unique instrument for advanced technology research that is not possible anywhere else. Tissue engineering in a space environment where “turnoff” gravity can be done is the most emerging field with high-value targets. The microgravity conditions allow the designing of novel biomaterials that cannot be produced on Earth but benefit Earth. Developing and manufacturing a biomaterial to address a space-based challenge could lead to novel biomaterials that will bring important applications in clinical medicine on Earth and/or for long-duration space missions. Up to today, there are only a handful of emerging biomaterials that have been tested in space, none of which have been used for their eventual function. This work is reporting on advances in space technology via the 3D magnetic assembler approach to have furthered the development of synthetic bone tissue constructs on board the ISS Russia Segment during the expeditions 61/62 with clear evidence of their function in preclinical conditions on Earth. The results have demonstrated both high levels of osteoinductive and - conductivity as well as a ultimate rate of tissue regeneration of space bone grafts.

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