Building resilient cervical cancer prevention through gender-neutral HPV vaccination

Man, Irene; Georges, Damien; Sankaranarayanan, Rengaswamy; Basu, Partha; Baussano, Iacopo

doi:10.1101/2023.01.17.23284655

Cited by 1 publication

(2 citation statements)

References 31 publications

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“…In two separate modeling studies conducted in Sweden 12 and India, 58 The condition underlying the gain in resilience by switching from girls-only to gender-neutral vaccination is the age difference between sexual partners, with men being on average older than women within sexual partnerships almost everywhere worldwide. 59 In cases of vaccination disruption, the birth cohorts of boys vaccinated before the disruption would indirectly protect the cohorts of younger girls who missed out on vaccination during the disruption period.…”

Section: Threat Mitigation: Building Up Resiliencementioning

confidence: 99%

“…To mitigate the negative impact on health of such public health crises as well as the waste of human, logistic, and financial resources, it would be farsighted to devise and implement pre‐emptive measures aimed at improving the resilience of public health programs. In two separate modeling studies conducted in Sweden 12 and India, 58 respectively, we have assessed the potential mitigation effect offered by gender‐neutral vaccination. In the former study, conducted before the coronavirus pandemic, and using a population‐based HPV transmission model adapted to account for Swedish HPV epidemiology and sexual behavior, we have illustrated how the addition of boys' vaccination to an ongoing program targeting girls only can make an HPV vaccination program more resilient to sudden and prolonged vaccination interruptions.…”

Section: Resilience Of Hpv Vaccination Programsmentioning

confidence: 99%

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Scientific approaches toward improving cervical cancer elimination strategies

Lehtinen,

Bruni,

Elfström

et al. 2024

Intl Journal of Cancer

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At the 2023 EUROGIN workshop scientific basis for strategies to accelerate the elimination of cervical cancer and its causative agent, human papillomavirus (HPV) were reviewed. Although some countries have reached key performance indicators toward elimination (>90% of girls HPV vaccinated and >70% of women HPV screened), most are yet to reach these targets, implying a need for improved strategies. Gender‐neutral vaccination, even with moderate vaccination coverage was highlighted as a strategy to achieve elimination more rapidly. It is more resilient against major disturbances in vaccination delivery, such as what happened during the coronavirus pandemic. Further, an analysis of ethical/legal issues indicated that female‐restricted vaccination is problematic. Extended catch‐up of vaccination with concomitant screening, and outreach to vulnerable groups were highlighted. Although birth cohorts with high coverage of HPV vaccination at school are protected against HPV, and HPVs have a very low reproductive rate in women above age 35, adult women below age 30 have inadequate direct protection. In addition to herd protection from gender‐neutral vaccination, this group can be protected by offering concomitant catch‐up HPV vaccination and HPV screening. Furthermore, hepatitis B vaccination experiences indicate that elimination cannot be achieved without prioritizing vulnerable/migrant populations. The long‐lasting durability of vaccination‐induced antibody responses suggests prolonged protection with HPV vaccines when adequately administrated. Finally, cost‐effectiveness modelling suggests that high‐coverage HPV vaccination in multiple population segments will be resource‐saving due to reduced need for screening. In summary, the workshop found that strategically optimal deployment of vaccination will accelerate elimination of HPV and cervical cancer.

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Section: Threat Mitigation: Building Up Resiliencementioning

confidence: 99%

Section: Resilience Of Hpv Vaccination Programsmentioning

confidence: 99%