Alternatives assessment is a science‐policy approach to support the informed substitution of chemicals of concern in consumer products and industries, with the intent of avoiding regrettable substitution and facilitating the transition to safer, more sustainable chemicals and products. The field of alternatives assessment has grown steadily in recent decades, particularly after the publication of specific frameworks and the inclusion of substitution and alternatives assessment requirements in a number of policy contexts. Previously, 14 research and practice needs for the field were outlined across five critical areas: comparative hazard assessment, comparative exposure characterization, lifecycle considerations, decision‐making and decision analysis, and professional practice. The aim of the current article is two‐fold: to highlight methodological advances in the growing field of alternatives assessment based on identified research and practice needs; and to propose areas for future developments. We assess advances in the field based on the analysis of broad literature review that captured 154 sources published from 2013‐2022. The results indicate that research conducted advanced many of the needs identified, but several remain under addressed. Although the field has clearly grown and taken root over the past decade, there are still research and practice gaps, most notably on the hazard assessment of mixtures or different forms of chemicals, the integration of life cycle considerations, and the development of practical approaches to address trade‐offs in decision‐making. We propose modifications to four of the prior research and practice needs in addition to new needs, including the development of standardized hazard assessment approaches for chemical mixtures as well as better integration of equity/justice considerations into assessments.