2019
DOI: 10.1016/j.lfs.2019.116783
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Bulbine frutescens phytochemical inhibits notch signaling pathway and induces apoptosis in triple negative and luminal breast cancer cells

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Cited by 65 publications
(70 citation statements)
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“…With the deepening of research, it is believed that more natural products that can regulate the mitochondria have the potential to be used in treating diseases, which is of utmost importance. Oxidative Medicine and Cellular Longevity [44] Oxidative stress Bulbine frutescens [37] Bullfrog oil [38] Orientin [40] Asparanin A [42] Gracillin [44] Apoptosis Bulbine frutescens [37] Orientin [40] Licochalcone A [41] Asparanin A [42] Parameritannin A-2 [43] Cernumidine [45] Mitochondrial membrane potential imbalance Bullfrog oil [38] Rhein [39] Asparanin A [42] Cernumidine [45] Neurodegenerative diseases…”
Section: Resultsmentioning
confidence: 99%
“…With the deepening of research, it is believed that more natural products that can regulate the mitochondria have the potential to be used in treating diseases, which is of utmost importance. Oxidative Medicine and Cellular Longevity [44] Oxidative stress Bulbine frutescens [37] Bullfrog oil [38] Orientin [40] Asparanin A [42] Gracillin [44] Apoptosis Bulbine frutescens [37] Orientin [40] Licochalcone A [41] Asparanin A [42] Parameritannin A-2 [43] Cernumidine [45] Mitochondrial membrane potential imbalance Bullfrog oil [38] Rhein [39] Asparanin A [42] Cernumidine [45] Neurodegenerative diseases…”
Section: Resultsmentioning
confidence: 99%
“…IGC-001, a β-Cantenin/ T Cell Factor mediated transcription antagonist, downregulates survivin expression leading to selective caspase activation in tumor cells [179]. Silencing Notch, using peptide antibiotic echinomycin, natural phytochemicals Xanthohumol and Bulbine frutescens, silences survivin in breast, ovary, liver and cholangiocarcinoma and has significant effects on stemness [180,181]. Other small molecules including Bay-11-7057, AKAP145, Metformin, Phenformin, GDP366, etc.…”
Section: Inhibitors Targeting Signaling Pathwaysmentioning
confidence: 99%
“…Accumulating research demonstrates that medicinal plants possess therapeutic potential against microbes and pathogen [ [7] , [8] , [9] ]. Recent reports suggest that natural-like products and their metabolites present in several plant spices exhibit remarkable potential to block SARS-CoV-2 M pro receptor [ [10] , [11] , [12] ].…”
Section: Introductionmentioning
confidence: 99%