Bulgarian Propolis Induces Analgesic and Anti-inflammatory Effects in Mice and Inhibits In Vitro Contraction of Airway Smooth Muscle

Paulino, Niraldo; Dantas, A.P.; Bankova, Vassya; Longhi, D.; Scremin, Amarilis; Castro, Solange L. de; Calixto, João B.

doi:10.1254/jphs.93.307

Cited by 78 publications

(69 citation statements)

References 35 publications

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“…The peripheral analgesic effect of the extracts was tested by using the writhing test. The involvement of central mechanisms was studied by using the hot-plate and tail-immersion tests, known to activate supraspinal nociceptive and spinal nociceptive pathways, respectively (Paulino et al, 2003;Bektas & Arslan, 2010). The formalin test was used to investigate both peripheral and central mechanisms (Tjolsen et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

Comparative study of the anti-inflammatory and antinociceptive effects of two varieties ofPunica granatum

Ouachrif¹,

Khalki²,

Chaı̈b³

et al. 2012

Pharmaceutical Biology

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Section: Discussionmentioning

confidence: 99%

Comparative study of the anti-inflammatory and antinociceptive effects of two varieties ofPunica granatum

Ouachrif¹,

Khalki²,

Chaı̈b³

et al. 2012

Pharmaceutical Biology

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“…Thus, our group has been engaged in experimental chemotherapy studies using propolis (Higashi & De Castro 1994, De Castro & Higashi 1995, Marcucci et al 2001, Prytzyk et al 2003, Paulino et al 2003, Salomão et al 2004). Propolis, a bee product collected from different plant exudates, is a complex mixture containing known bioactive constituents, such as flavonoids, phenolic acids and esters, terpenes, sesquiterpenes, aromatic aldehydes, and alcohols (Marcucci 1995 In temperate zones, bud exudates from poplar trees (Populus spp.)…”

Section: Extracts From a Bulgarian Propolis With Known Chemical Compmentioning

confidence: 99%

The effect of Bulgarian propolis against Trypanosoma cruzi and during its interaction with host cells

Dantas

Salomão

Barbosa

et al. 2006

Mem. Inst. Oswaldo Cruz

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Propolis has shown activity against pathogenic microorganisms that cause diseases in humans and animals. The ethanol (Et-Blg) and acetone (Ket-Blg) extracts from a Bulgarian propolis, with known chemical compositions, presented similar activity against tissue culture-derived amastigotes. The treatment of Trypanosoma cruzi-infected skeletal muscle cells with Et-Blg led to a decrease of infection and of the intracellular proliferation of amastigotes, while damage to the host cell was observed only at concentration 12.5 times higher than those affecting the parasite. Ultrastructural analysis of the effect of both extracts in epimastigotes revealed that the main targets were the mitochondrion and reservosomes. Et-Blg also affected the mitochondrion-kinetoplast complex in trypomastigotes, offering a potential target for chemotherapeutic agents.Key words: propolis -natural products -Trypanosoma cruzi -Chagas disease Chagas disease, caused by the trypanosomatid protozoan Trypanosoma cruzi, is endemic in Latin America. Initially restricted to natural ecotopes, with transmission among small autochthonous mammals by hematophagous Triatominae bugs, the occupation by humans of such ecotopes led to the establishment of the vectors in human dwellings, changing the characteristic of the disease from zoonotic to antropozoonotic. In humans, the acute phase results in 2-8% mortality, specially among children, while in the chronic phase most patients remain asymptomatic and about 30 to 40% of the cases develop symptoms of cardiac or digestive lesions. The World Health Organization estimates that about 18 million people are infected with T. cruzi (WHO 2002). The available drugs for the clinical treatment, the nitroderivatives benznidazole and nifurtimox, are unsatisfactory. They present variable healing effects during the acute phase according to the geographical region and require long term treatment, besides presenting frequent toxic side effects and limited efficacy in the chronic stage (reviewed in Coura & De Castro 2001).In this context, there is an intense search for new synthetic compounds and natural products for treatment of Chagas disease. Thus, our group has been engaged in experimental chemotherapy studies using propolis (Higashi & De Castro 1994, De Castro & Higashi 1995, Marcucci et al. 2001, Prytzyk et al. 2003, Paulino et al. 2003, Salomão et al. 2004). Propolis, a bee product collected from different plant exudates, is a complex mixture containing known bioactive constituents, such as flavonoids, phenolic acids and esters, terpenes, sesquiterpenes, aromatic aldehydes, and alcohols (Marcucci 1995). In temperate zones, bud exudates from poplar trees (Populus spp.) are the main source of flavonoid-rich propolis, which are rich in flavonoids (reviewed in Bankova et al. 2000).During the last decades, an increasing number of studies on the chemical composition, biological activity, and therapeutic uses of propolis has been published (reviewed in De Castro 2001). In recent studies with a Bulgarian propolis sample, we ...

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“…In fact, various biological properties have been demonstrated and attributed to different types of propolis, including antibacterial, antifungal, antiprotozoal, antioxidant, antitumor, anti-infl ammatory, anesthetic, wound healing, immunomodulatory, antiproliferative and anticariogenic activities (Dobrowolski et al, 1991;Ivanovska et al, 1995;Moura et al, 1999;Kujumgiev et al, 1999;Isla et al, 2001;Chen et al, 2004;Simões et al, 2004;Duran et al, 2006;Medic-Saric et al, 2009;Araujo et al, 2010;Sforcin, 2007;Libério et al, 2009;Pagliarone et al, 2009, Paulino et al, 2003.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

Araújo

Libério

Guerra

et al. 2012

Rev. bras. farmacogn.

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Many biological properties have been attributed to various types of propolis, including anti-inflammatory, antimicrobial, antioxidant, antitumor, wound healing, and immunomodulatory activities. This article reviewed studies published that investigated the anti-inflammatory activity of propolis of different origins and/ or its isolated components, focusing on the mechanisms of action underlying this activity and also addressing some aspects of immunomodulatory effects. The search was performed of the following databases: PubMed, Science Direct, HighWire Press, Scielo, Google Academics, Research Gate and ISI Web of Knowledgement. The anti-inflammatory activity was associated with propolis or compounds such as polyphenols (flavonoids, phenolic acids and their esters), terpenoids, steroids and amino acids. CAPE is the most studied compounds. The main mechanisms underlying the anti-inflammatory activity of propolis included the inhibition of cyclooxygenase and consequent inhibition of prostaglandin biosynthesis, free radical scavenging, inhibition of nitric oxide synthesis, reduction in the concentration of inflammatory cytokines and immunosuppressive activity. Propolis was found to exert an antiinflammatory activity in vivo and in vitro models of acute and chronic inflammation and others studies, indicating its promising potential as anti-inflammatory agent of natural origin and as a source of chemical compounds for the development of new drugs.

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Bulgarian Propolis Induces Analgesic and Anti-inflammatory Effects in Mice and Inhibits In Vitro Contraction of Airway Smooth Muscle

Cited by 78 publications

References 35 publications

Comparative study of the anti-inflammatory and antinociceptive effects of two varieties ofPunica granatum

Comparative study of the anti-inflammatory and antinociceptive effects of two varieties ofPunica granatum

The effect of Bulgarian propolis against Trypanosoma cruzi and during its interaction with host cells

Mechanisms of action underlying the anti-inflammatory and immunomodulatory effects of propolis: a brief review

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