Bulimia nervosa treatment: A systematic review of randomized controlled trials

Abstract

Evidence for medication or behavioral treatment for BN is strong, for self-help is weak; for harms related to medication is strong but either weak or nonexistent for other interventions; and evidence for differential outcome by sociodemographic factors is nonexistent. Attention to sample size, standardization of outcome measures, attrition, and reporting of abstinence from target behaviors are required. Longer follow-up intervals, innovative treatments, and attention to sociodemographic factors would enhance the literature.

Acompanhamento da evolução dos distúrbios de imagem corporal em pacientes com bulimia nervosa, ao longo do tratamento multiprofissional

“…A terapia, a intervenção nutricional, o suporte psiquiátrico, a indicação do uso de medicamentos específicos e a diminuição da restrição ajudam a diminuir a ansiedade, a tristeza e outros sentimentos considerados facilitadores de episódios de compulsão alimentar e de indução de vômitos 18,19 .…”

CYP2D6 polymorphism in patients with eating disorders

“…[11][12] Curiously, fluoxetine-recommended doses for the treatment of binge eating and purging in ED are higher (60 mg per day) than clinically recommended dosages for other disorders. 3,20 Further research is required to determine whether the use of higher doses of CYP2D6 substrates or normal doses under polytherapy in patients with ED might be related to a higher frequency of individuals with high CYP2D6 metabolic capacity.…”

“…1 CYP2D6 is involved in the metabolism of drugs used in the treatment of eating disorders (EDs), such as the antidepressant fluoxetine. 2,3 In clinical practice, women with ED are also likely to take other drugs metabolized by CYP2D6 (paroxetine, fluvoxamine, venlafaxine, citalopram) for treating comorbid or lifetime psychiatric disorders such as major depression, obsessive-compulsive disorder and so on. 4 CYP2D6 is also involved in endogenous metabolism, 4 in particular in regeneration of serotonin from 5-methoxytryptamine.…”

Towards a Comprehensive Model of Recovery

“…At least with respect to bulimia nervosa and binge eating disorder, there is compelling evidence for the effect of many treatments, notably cognitive therapy, interpersonal therapy, family therapy and guided self-help (Fairburn & Harrison, 2003;Shapiro et al, 2007). Unfortunately, treatment effects could for many reasons not be equalised with recovery (Keel & Mitchell, 1997;Strober et al, 1997;Keel & Brown, 2010).…”