Bulletin of Clinical Studies in Q1 2021

Kuznetsova, Yulia А.; Smirnova, Anna V.

doi:10.47619/2713-2617.zm.2021.v2i2;101-108

City Healthcare

2021

DOI: 10.47619/2713-2617.zm.2021.v2i2;101-108

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Bulletin of Clinical Studies in Q1 2021

Yulia А. Kuznetsova

Anna V. Smirnova

Abstract: Purpose. To evaluate clinical trials data since January 2021 till March 2021. Materials and methods. The information about clinical trial’s approvals from the state register of medicines of Russian Federation ministry of health website was used as the main source of the original data concerning clinical trials. The register contains all the information relating to clinical trials in Russian Federation. Results. Clinical trials data was analyzed by its type (international, local, bioequivalence), sponsorship (f… Show more

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2024

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New horizons in comprehensive rehabilitation of melanoma patients: improved outcomes through an integrated approach to immunotherapy

Koneva,

Mochalova,

Suetina

2024

Physiotherapist

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Abstract. The article discusses the importance of a comprehensive rehabilitation approach for melanoma patients when treated with immunotherapy. By focusing on innovative treatments, the study highlights the need to integrate nutritional support, physical therapy, magnetic therapy, and psychological support to improve quality of life and enhance the effectiveness of immunotherapy regimens. Purpose of the study: to evaluate the impact of the multidisciplinary rehabilitation program on physiological functions, psycho-emotional well-being, general antitumor effect, and quality of life of patients with melanoma. Materials and methods. The study included 135 patients diagnosed with melanoma who received a course of immunotherapy. In the study group (the main group), a complex of rehabilitation techniques (magnetic therapy, therapeutic exercises, nutritional support, psychological support) was used, while in the control group, the patients did not undergo the accompanying comprehensive rehabilitation program. Treatment effectiveness was assessed in accordance with iRECIST 1.1 criteria; to assess the quality of life, the Russian version of the EORTC QLQ-C30 questionnaire was used. Results. The patients of the study group showed an improvement in their general physical condition and a decrease in the intensity of some side effects of treatment. The patients in the control group also showed changes in their health status, but they were less pronounced compared to the study group. Adverse events during treatment occurred in 55 % of the patients in the study group and in 74 % of the patients in the control group. The patients in the study group noted an improvement in quality of life by 25 %, while in the patients in the control group this indicator was 12 %. An 18 % improvement in general condition was noted by the patients in the study group, while the patients in the control group noted an 8 % improvement in general well-being. Conclusion. The implementation of the multidisciplinary rehabilitation approach, including nutritional support, therapeutic exercises, magnetic therapy, and psychological support, demonstrates significant improvements in symptom management and quality of life in melanoma patients undergoing immunotherapy.

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New horizons in comprehensive rehabilitation of melanoma patients: improved outcomes through an integrated approach to immunotherapy

Koneva,

Mochalova,

Suetina

2024

Physiotherapist

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show abstract

New horizons in comprehensive rehabilitation of patients with melanoma: improved outcomes through an integrated approach to immunotherapy

Mochalova,

Koneva,

Suetina

2024

Physiotherapist

View full text Add to dashboard Cite

Abstract. The article discusses issues of a comprehensive rehabilitation approach for patients with melanoma when treated with immunotherapy. By focusing on innovative treatments, the study highlights the need to integrate nutritional support, physical therapy, magnetic therapy and psychological support to improve quality of life and enhance the effectiveness of immunotherapy regimens. Purpose. The study aims to evaluate the impact of a multidisciplinary rehabilitation program on improving physiological functions, psychoemotional well-being and the impact on the overall antitumor response, which together can improve the quality of life of patients with melanoma. Materials and methods. The study included 135 patients diagnosed with melanoma who received a course of immunotherapy. In the study group (the main group), a complex of rehabilitation techniques was used (magnetic therapy, physical therapy, nutritional support, psychological support), while in the control group, patients did not undergo an accompanying comprehensive rehabilitation program. Treatment effectiveness was assessed in accordance with iRECIST 1.1 criteria. To assess the quality of life, the Russian version of the EORTC QLQ-C30 questionnaire was used. The severity of adverse events was assessed according to CTCAE 5.0 criteria. Results. Patients from the main group who received comprehensive rehabilitation support along with immunotherapy showed an improvement in their general physical condition and a decrease in the intensity of some side effects of treatment. Patients in the control group who received only standard immunotherapy also showed changes in their health status, but these changes were less pronounced compared to the main group. Adverse events during treatment occurred in 55 % of patients in the main group and in 74 % in the control group. Patients in the main group noted an improvement in quality of life by 25 %, while in patients in the control group this figure was 12 %. An 18 % improvement in general condition was noted by patients in the main group, while patients in the control group noted an 8 % improvement in general condition. Conclusion. Implementation of a multidisciplinary rehabilitation approach, including nutritional support, physical therapy exercises, magnetic therapy, and psychological support, demonstrates significant improvements in symptom management and quality of life in melanoma patients undergoing immunotherapy.

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Bulletin of Clinical Studies in Q1 2021

Cited by 2 publications

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New horizons in comprehensive rehabilitation of melanoma patients: improved outcomes through an integrated approach to immunotherapy

New horizons in comprehensive rehabilitation of melanoma patients: improved outcomes through an integrated approach to immunotherapy

New horizons in comprehensive rehabilitation of patients with melanoma: improved outcomes through an integrated approach to immunotherapy

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