Bullous acral erythema and concomitant pigmentation on the face and occluded skin

Özkaya‐Bayazit, Esen; Diz‐Küçükkaya, Reyhan; Akasya, Esra; Büyükbabanı, Nesimi; Öncü, Şeref; Pekçelen, Yüksel

doi:10.1046/j.1468-3083.2000.00037.x

Cited by 10 publications

(9 citation statements)

References 15 publications

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“…The inhibitory effect of CsA on melanogenesis in vitro did not accord with previously reported clinical observations (6,7,9) including our experiences in which the patients presented with skin hyperpigmentation during CsA therapy. The present study suggests that the skin pigmentation in those patients may have increased through mechanisms other than the direct effects of CsA on melanocytes.…”

Section: Resultscontrasting

confidence: 74%

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Effect of Cyclosporin A on Melanogenesis in Cultured Human Melanocytes

Lee

Kang

2003

Pigment Cell Research

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Cyclosporin A (CsA) is a widely used immunosuppressant. Reports on the effect of CsA on hyperpigmentation in patients appear inconsistent, and the effect of CsA on skin pigment cells (melanocytes) in vitro is unknown. We examined the effect of CsA on human melanocyte proliferation and melanogenesis in vitro. Melanocyte proliferation was dose-dependently inhibited by 0.1-10 lM CsA, with no effect on cell viability. Melanocytes incubated with 10 lM CsA for 6 days showed decreased pigmentation and tyrosinase activity. Western blot analysis using an anti-tyrosinase antibody revealed that CsA (0.1-10 lM) decreased tyrosinase protein levels in a dose-dependent manner. Northern blot analysis showed similar effects on tyrosinase mRNA levels. These effects of CsA on melanogenesis in vitro are not consistent with suggestions that systemic CsA therapy causes patient skin hyperpigmentation.

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Section: Resultscontrasting

confidence: 74%

“…Ozkaya‐Bayazit et al. (7) described a patient with acute myeloid leukemia who developed hyperpigmentation on both the face and occluded skin during therapy with CsA, daunorubicin and cytarabine. However, it is not clear which drug might have contributed to the development of hyperpigmentation.…”

Section: Introductionmentioning

confidence: 99%

Effect of Cyclosporin A on Melanogenesis in Cultured Human Melanocytes

Lee

Kang

2003

Pigment Cell Research

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“…The hyperpigmentation resolved discontinuing CsA therapy. Another case of hyperpigmentation during CsA therapy has been described by Ozkaya-Bayazit et al [43] in a patient undergoing therapy with CsA, daunorubicin, and cytarabin for acute myeloid leukaemia. In this report, however, the effective contribution of CsA to the development of hyperpigmentation is not clear.…”

Section: Immunosuppression and Melanocyte Proliferationmentioning

confidence: 84%

Immunosuppression and melanocyte proliferation

et al. 2009

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Melanocytes are pigmented cells derived from the neural crest; their proliferation is restrained by immune system. The eruption of nevi after an immunosuppressive condition is a peculiar phenomenon indicating that the immune system may play a major role in limiting proliferation of melanocytes. In this review, we analyze the role of immunosuppressive regimens on melanocyte proliferation. In particular, we discuss the eruptive nevi phenomenon, which is determined by the inability of the immune system to inhibit melanocyte proliferation. These clinical observations indicate that the immune system has a pivotal role in restraining melanocyte proliferation. However, although the role of the immune system in the development of nonmelanoma skin cancer has been shown clearly in several studies involving organ transplant patients, the role of immunosuppression in melanoma genesis has not yet been established. Further investigations are required to establish the real immunogenicity of melanoma, particularly in the light of the dichotomy between the eruptive nevi phenomenon in immunosuppressed patients and the low incidence of melanoma in transplanted patients.

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“…of cases of skin hyperpigmentation under CsA is not very convincing due to simultaneous diseases or treatments [3,4] . Opposite effects have been claimed for hair pigmentation, darkening [5] or poliosis [6] .…”

mentioning

confidence: 99%

Tacrolimus and the Pigmentary System

Taı̈eb¹

2005

Dermatology

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Bullous acral erythema and concomitant pigmentation on the face and occluded skin

Cited by 10 publications

References 15 publications

Effect of Cyclosporin A on Melanogenesis in Cultured Human Melanocytes

Effect of Cyclosporin A on Melanogenesis in Cultured Human Melanocytes

Immunosuppression and melanocyte proliferation

Tacrolimus and the Pigmentary System

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