Bullous and Necrotic Skin Lesions in a Cirrhotic Patient

Malek, Alexandre; Arias, César A.; Pankow, Stephanie; Olmedo-Reneaum, Alejandro

doi:10.1093/cid/ciz862

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2022

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“…The most frequent sites of cryptococcal disease include the skin, lungs, and central nervous system but can also involve other sites such as bones [ 17–19 ]. Cutaneous lesions may include ulcers, plaques, pustules, nodules, abscesses, cellulitis, umbilicated papules, or hemorrhagic bullae [ 20 , 21 ]. Skin involvement reflects either a cutaneous manifestation of disseminated cryptococcosis, with antigenemia or other sites of infection identified, or localized cutaneous cryptococcosis, without antigenemia.…”

Section: Discussionmentioning

confidence: 99%

Sweet Syndrome Imitating Cutaneous Cryptococcal Disease

Jordan

Graciaa

et al. 2022

Open Forum Infectious Diseases

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Cryptococcoid Sweet syndrome is a rare histologic variant of the neutrophilic dermatosis presenting clinically with skin lesions typical of classical Sweet syndrome but with yeast-like structures suggestive of Cryptococcus on histopathology. Histochemical stains for fungus and cultures are negative while staining for myeloperoxidase is positive. We present two cases of cryptococcoid Sweet syndrome with atypical skin manifestations, including hemorrhagic bullae and plaques, and provide a brief review of the literature. Clinicians should be aware that this variant of Sweet syndrome can present with uncommon clinical findings and has histopathology findings suggestive of Cryptococcus species.

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Section: Discussionmentioning

confidence: 99%