Bullous diseases: Kids are not just little people

Diffuse scaling and crusting on a 15‐year‐old boy

“…Considered more benign than pemphigus vulgaris (PV), PF spares mucosal surfaces, but may still carry significant morbidity in patients on prolonged immunosuppressant therapy due to risk of infection and malignancy . PF typically follows a mild course with short duration in children, with most cases remitting or resolving within one year . However, severe cases with progression to erythroderma have been documented in this population …”

Combination therapy with prednisone and cyclophosphamide in a 14-year-old boy with pemphigus foliaceus – a case report

“…Doniesienia w piśmiennictwie dotyczące leczenia PF u dzieci są ograniczone. Mimo występowania podobnych cech klinicznych u dorosłych i dzieci niewła-ściwe wydaje się dokładne przekładanie schematów terapeutycznych zalecanych u dorosłych na populację dziecięcą [8]. Ważne jest przedstawianie efektów zastosowanego leczenia w celu wprowadzenia jednoznacznych zaleceń dotyczących najskuteczniejszej i najbezpieczniejszej terapii u dzieci.…”

“…Even though the clinical features of the disease in adults and children are similar, it does not seem appropriate to extrapolate therapeutic regimens from adults to the paediatric population [8].…”

Differential Diagnosis of Diaper Dermatitis

“…Lesions in the diaper area may be exacerbated by contact irritant or allergic dermatitis, but can be effectively treated with oral dapsone. 17 …”

“…17,18 Hereditary mechanobullous diseases like epidermolysis bullosa typically present in the newborn or early infancy with blisters and erosions of the skin and mucous membranes in areas prone to trauma (including the hands, feet, elbows, knees, and periorificial skin particularly the diaper area). 18 These disorders are usually categorized based on severity of skin separation, and there is much variability in expression of clinical findings in each group.…”